Spontaneous corneal neovascularization in Reden mouse

H. Takenouchi, T. Murata, Y. Kumano, A. Tawara, T. Ishibashi, K. Ohta, H. Sasaki, H. Inomata

Research output: Contribution to journalArticlepeer-review


Purpose. To investigate the mechanism of neovascularization in the cornea of Reden mouse which has the semidominant mutation reported by Eicher and Varnum in 1986 and has been used as an animal model of hair loss. Methods. 6 Reden mice were used; 4 of them were 8 months old and 2 was 12 months old. Their corneas were observed clinically and histopathologically. Results. Macroscopically, corneal neovascularization was observed in 5 of 8 corneas taken from 8 months old mice, 3 of 4 corneas taken from 12 months old mice. New vessels originating from the limbal vessels formed fine capillary networks at the center of the cornea. Microscopically, the central portion of the corneal stroma was markedly thickened due to neovascularization and proliferation of spindle shaped cells. Descement's membrane and endothelium remained intact. Different from corneal pannus that is usually restricted to the superficial portion of the corneal stroma, this neovascularization was observed in the whole thickness of the involved corneal stroma. Marked epidermalization with intercellular bridges and keratinization, of covering corneal epithelium was also noted. Conclusions. Since corneal neovascularization in Reden mouse occurs spontaneously without any artificial stimulus, it is a useful animal model to investigate the mechanisms of corneal neovascularization.

Original languageEnglish
Pages (from-to)S1014
JournalInvestigative Ophthalmology and Visual Science
Issue number3
Publication statusPublished - Feb 15 1996

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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