TY - JOUR
T1 - Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff.
AU - Sivasothy, Yasodha
AU - Hadi, A. Hamid A.
AU - Mohamad, Khalit
AU - Leong, Kok Hoong
AU - Ibrahim, Halijah
AU - Sulaiman, Shaida Fariza
AU - Ooi, Kheng Leong
AU - Awang, Khalijah
N1 - Funding Information:
The authors acknowledge the Research University Grant RG 017/09 SUS and RG 008-09B10 provided by University Malaya along with 16-02-03-6024 provided by MOSTI and 05-01-05-SF01001 Escience Fund provided by the Ministry of Agriculture and Agro-based Industry Malaysia that has resulted in this article. The authors wish to thank Mr. Teo, Mr. Rafly Syamsir and Mr. Din in assisting with the preparation of the voucher specimen along with Ms. Chan Gomathi, Mr. Chong Soon Lim, and Mr. Fateh Ngaliman for the measurement of the NMR spectra and Ms. Hazrina Hazni for the recoding of the LC–MS-IT-TOF data.
PY - 2012/6/1
Y1 - 2012/6/1
N2 - The rhizomes of Zingiber spectabile yielded a new dimeric flavonol glycoside for which the name kaempferol-3-O-(4″-O-acetyl)-α-l- rhamnopyranoside-(I-6,II-8)-kaempferol-3-O-(4″-O-acetyl) -α-l-rhamnopyranoside; spectaflavoside A (1) was proposed, along with kaempferol and its four acetylrhamnosides (2-6), demethoxycurcumin (7) and curcumin (8). The structure of spectaflavoside A was elucidated by spectroscopic methods including, 1D and 2D NMR techniques. This is the first report on the occurrence of a dimeric flavonol glycoside in the Zingiberaceae and the second in nature. Spectaflavoside A was found to be a potent iron chelating agent.
AB - The rhizomes of Zingiber spectabile yielded a new dimeric flavonol glycoside for which the name kaempferol-3-O-(4″-O-acetyl)-α-l- rhamnopyranoside-(I-6,II-8)-kaempferol-3-O-(4″-O-acetyl) -α-l-rhamnopyranoside; spectaflavoside A (1) was proposed, along with kaempferol and its four acetylrhamnosides (2-6), demethoxycurcumin (7) and curcumin (8). The structure of spectaflavoside A was elucidated by spectroscopic methods including, 1D and 2D NMR techniques. This is the first report on the occurrence of a dimeric flavonol glycoside in the Zingiberaceae and the second in nature. Spectaflavoside A was found to be a potent iron chelating agent.
UR - http://www.scopus.com/inward/record.url?scp=84861189407&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861189407&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2012.02.064
DO - 10.1016/j.bmcl.2012.02.064
M3 - Article
C2 - 22546674
AN - SCOPUS:84861189407
SN - 0960-894X
VL - 22
SP - 3831
EP - 3836
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 11
ER -