TY - JOUR
T1 - Specific roles of sodium for the formation process of manganese-substituted octacalcium phosphate
AU - Sugiura, Yuki
AU - Horie, Masanori
AU - Tsuchiya, Akira
AU - Makita, Yoji
N1 - Funding Information:
This study is financially supported by the priority issue of the Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), research grant, the foundation for the promotion of ion engineering and, KAK-ENHI for Young Researcher, JP19K19081. We thank Y. Uryu and T. Nakanishi for helping with FTIR measurements. This study is partially supported by the Research Center for Industrial Science & Technology, Kagawa Industry Support Foundation (RIST Kagawa).
Publisher Copyright:
© 2022 Mineralogical Society of America.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - In the field of biomaterials, octacalcium phosphate (OCP) and biocompatible elements doped with OCP-based materials are attractive materials for new bone substitution because they could be used to control the bone remodeling process in patients with bone diseases. Manganese (Mn) might be a good substitutional element candidate because of its regulation process of bone remodeling for controlling osteo-cellular activities. However, Mn strongly inhibits OCP formation. This study demonstrates that the sodium (Na)-induced OCP formation enhancing the HPO4-OH layer structure of the OCP can overcome this Mn inhibition effect. The Mn-substituted OCP can be fabricated from the coexisting solutions of Na and Mn. The results show that the Mn-substituted OCP-induced Na (OCP-Mn,Na) showed a 4.7° peak in the X-ray diffraction pattern. The sub-peaks at 9.2° and 9.7° of the OCP disappeared, but an extra peak at 9.3° was observed. The thermal stability of the OCP-Mn,Na was significantly lower than that of the conventional OCP because the layer structure of the OCP-Mn,Na decomposed above ~70 °C. This ionic conjugation to Mn is a unique phenomenon for Na, unlike other cations.
AB - In the field of biomaterials, octacalcium phosphate (OCP) and biocompatible elements doped with OCP-based materials are attractive materials for new bone substitution because they could be used to control the bone remodeling process in patients with bone diseases. Manganese (Mn) might be a good substitutional element candidate because of its regulation process of bone remodeling for controlling osteo-cellular activities. However, Mn strongly inhibits OCP formation. This study demonstrates that the sodium (Na)-induced OCP formation enhancing the HPO4-OH layer structure of the OCP can overcome this Mn inhibition effect. The Mn-substituted OCP can be fabricated from the coexisting solutions of Na and Mn. The results show that the Mn-substituted OCP-induced Na (OCP-Mn,Na) showed a 4.7° peak in the X-ray diffraction pattern. The sub-peaks at 9.2° and 9.7° of the OCP disappeared, but an extra peak at 9.3° was observed. The thermal stability of the OCP-Mn,Na was significantly lower than that of the conventional OCP because the layer structure of the OCP-Mn,Na decomposed above ~70 °C. This ionic conjugation to Mn is a unique phenomenon for Na, unlike other cations.
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U2 - 10.2138/am-2021-7901
DO - 10.2138/am-2021-7901
M3 - Article
AN - SCOPUS:85130348449
SN - 0003-004X
VL - 107
SP - 896
EP - 903
JO - American Mineralogist
JF - American Mineralogist
IS - 5
ER -