Solitary asymptomatic thyroid metastasis from hepatocellular carcinoma detected by FDG-PET/CT

Takeo Toshima, Akinobu Taketomi, Ken Shirabe, Kazuki Takeishi, Takashi Motomura, Youhei Mano, Kazutoyo Morita, Takasuke Fukuhara, Keishi Sugimachi, Yasuhiro Maruoka, Koichiro Abe, Tsuyoshi Tajima, Yoshihiko Maehara

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9 Citations (Scopus)


Thyroid metastases from hepatocellular carcinoma (HCC) seldom occur and are often difficult to diagnose because of their asymptomatic clinical course. We evaluated a very rare case of solitary thyroid metastasis from HCC that showed high uptake of fluorine-18 fluorodeoxyglucose (FDG), when imaged using fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). The patient was a 74-year-old man and presented with a remarkably elevated des-gamma-carboxy prothrombin level of 1,157 mAU/ml 22 months after hepatic lobectomy. FDG-PET/CT imaging revealed a hypodense tumor with high FDG uptake, with a maximum standardized uptake value of 5.2 in the thyroid left lobe. Solitary thyroid metastasis from HCC was suspected and subsequent fine needle aspiration did indeed reveal HCC. The patient received left thyroidectomy with left regional lymph node dissection. Two months after left thyroidectomy, contrast-enhanced computed tomography showed local recurrence, and the patient received ongoing radiotherapy treatment. To our knowledge, the present study is the first to demonstrate the feasibility of FDG-PET/CT in the diagnosis and management of clinically diagnosed, asymptomatic, solitary thyroid metastasis from HCC.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalCase Reports in Gastroenterology
Issue number2
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Gastroenterology


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