TY - JOUR
T1 - SOCS
T2 - Negative regulators of cytokine signaling for immune tolerance
AU - Yoshimura, Akihiko
AU - Ito, Minako
AU - Mise-Omata, Setsuko
AU - Ando, Makoto
N1 - Funding Information:
This work was supported by JSPS KAKENHI 17H06175, 21H05044, 19H04817, 21K19382, 21H02719, 21H00432, AMED-CREST 21gm1110009, AMED-PRIME 21gm6210012, the Princess Takamatsu Cancer Research Fund, the Yasuda Medical Foundation, the Kishimoto Family Foundation, the Tomizawa Jun-ichi and Keiko Fund of Molecular Biology Society of Japan for Young Scientist, the Mitsubishi Foundation, the Mochida Memorial Foundation for Medical and Pharmaceutical Research, the Takeda Science Foundation, the Uehara Memorial Foundation, the Naito Foundation, the Kanae Foundation, the SENSHIN Medical Research Foundation, the Astellas Foundation for Research on Metabolic Disorders, the Inoue Research Award for Young Scientists, a Life Science Research Award and Keio Gijuku Academic Developmental Funds
Publisher Copyright:
© 2021 The Japanese Society for Immunology. 2021. All rights reserved.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Cytokines are important intercellular communication tools for immunity. Many cytokines promote gene transcription and proliferation through the JAK/STAT (Janus kinase/signal transducers and activators of transcription) and the Ras/ERK (GDP/GTP-binding rat sarcoma protein/extracellular signal-regulated kinase) pathways, and these signaling pathways are tightly regulated. The SOCS (suppressor of cytokine signaling) family members are representative negative regulators of JAK/STAT-mediated cytokine signaling and regulate the differentiation and function of T cells, thus being involved in immune tolerance. Human genetic analysis has shown that SOCS family members are strongly associated with autoimmune diseases, allergy and tumorigenesis. SOCS family proteins also function as immune-checkpoint molecules that contribute to the unresponsiveness of T cells to cytokines.
AB - Cytokines are important intercellular communication tools for immunity. Many cytokines promote gene transcription and proliferation through the JAK/STAT (Janus kinase/signal transducers and activators of transcription) and the Ras/ERK (GDP/GTP-binding rat sarcoma protein/extracellular signal-regulated kinase) pathways, and these signaling pathways are tightly regulated. The SOCS (suppressor of cytokine signaling) family members are representative negative regulators of JAK/STAT-mediated cytokine signaling and regulate the differentiation and function of T cells, thus being involved in immune tolerance. Human genetic analysis has shown that SOCS family members are strongly associated with autoimmune diseases, allergy and tumorigenesis. SOCS family proteins also function as immune-checkpoint molecules that contribute to the unresponsiveness of T cells to cytokines.
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U2 - 10.1093/intimm/dxab055
DO - 10.1093/intimm/dxab055
M3 - Review article
C2 - 34121041
AN - SCOPUS:85121207092
SN - 0953-8178
VL - 33
SP - 711
EP - 716
JO - International immunology
JF - International immunology
IS - 12
ER -
