Social isolation stress exacerbates autoimmune disease in MRL/lpr mice

Yoichi Chida, Nobuyuki Sudo, Chiharu Kubo

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


The potential physiological mechanisms explaining an influence of psychosocial stress on autoimmune diseases remain undetermined. Exposure of chronic social isolation stress to MRL/lpr mice significantly enhanced the degree of proteinuria after 20 weeks of age and reduced the survival rate. The serum anti-dsDNA IgG2a levels were increased significantly by stress at 19 weeks of age, which was simultaneously accompanied by inhibition of the serum corticosterone elevation. Furthermore, stress caused increased IFN-γ production from anti-CD3-stimulated splenic mononuclear cells, whereas IL-4 and IL-10 production decreased. These results indicated that isolation stress exacerbated autoimmune disease in MRL/lpr mice, the possible mechanism for which might be related to stress-induced dysregulation of Th1/Th2 balance and inhibition of the blood corticosterone response to inflammatory stimuli.

Original languageEnglish
Pages (from-to)138-144
Number of pages7
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - Jan 2005

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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