Small-molecule fluorescent probes for specific RNA targets

Asako Murata, Shin Ichi Sato, Yoshinori Kawazoe, Motonari Uesugi

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

A method was developed that uses small molecules as fluorescent probes to detect specific mRNAs. In this approach, the fluorescence of fluorophore–quencher conjugates is restored by the binding of an mRNA aptamer tag to the quencher segment of the molecules. The method allows real-time detection of mRNA transcripts in vitro.

Original languageEnglish
Pages (from-to)4712-4714
Number of pages3
JournalChemical Communications
Volume47
Issue number16
DOIs
Publication statusPublished - Apr 4 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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