TY - JOUR
T1 - Sirtuin 7 is involved in the consolidation of fear memory in mice
AU - Islam, Md Safiqul
AU - Wei, Fan Yan
AU - Ohta, Kunimasa
AU - Shigematsu, Naoki
AU - Fukuda, Takaichi
AU - Tomizawa, Kazuhito
AU - Yoshizawa, Tatsuya
AU - Yamagata, Kazuya
N1 - Funding Information:
We thank Dr. Eva Bober for providing Sirt7 KO mice. This work was supported by a Grant-in-Aid for Scientific Research (B) ( 16H05328 ) (K.Y.) and Scientific Research on Innovative Areas “Stem Cell Aging and Disease” ( 17H05650 ) from MEXT, Japan (T.Y.), and by a grant from Uehara Memorial Foundation (K.Y.) and the Naito Foundation (K.Y.).
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Sirtuin 7 (SIRT7) is an NAD+-dependent deacetylase/deacylase, and is involved in a variety of biological processes relevant to the transcription of rRNA, the DNA damage response, tumorigenesis, and metabolism. SIRT7 mRNA is expressed ubiquitously, including in the brain, but there is no detailed information about the anatomical distribution and functional role of SIRT7 in the brain. Here, we demonstrated that SIRT7 is widely expressed in the mouse brain, including in the cortex, striatum, thalamus, hippocampus, and amygdala. Behavioral examinations revealed that Sirt7 knockout (KO) and control mice showed similar levels of freezing behavior immediately after a fear response, but a significant decrease of freezing behavior at 24 h after fear conditioning was observed in Sirt7 KO mice. Histological analysis revealed that there is no apparent structural abnormality of the amygdala and hippocampus, which are regions involved in fear memory consolidation, in Sirt7 KO mice. Our results indicate that SIRT7 is involved in the consolidation of fear memory.
AB - Sirtuin 7 (SIRT7) is an NAD+-dependent deacetylase/deacylase, and is involved in a variety of biological processes relevant to the transcription of rRNA, the DNA damage response, tumorigenesis, and metabolism. SIRT7 mRNA is expressed ubiquitously, including in the brain, but there is no detailed information about the anatomical distribution and functional role of SIRT7 in the brain. Here, we demonstrated that SIRT7 is widely expressed in the mouse brain, including in the cortex, striatum, thalamus, hippocampus, and amygdala. Behavioral examinations revealed that Sirt7 knockout (KO) and control mice showed similar levels of freezing behavior immediately after a fear response, but a significant decrease of freezing behavior at 24 h after fear conditioning was observed in Sirt7 KO mice. Histological analysis revealed that there is no apparent structural abnormality of the amygdala and hippocampus, which are regions involved in fear memory consolidation, in Sirt7 KO mice. Our results indicate that SIRT7 is involved in the consolidation of fear memory.
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U2 - 10.1016/j.bbrc.2017.10.159
DO - 10.1016/j.bbrc.2017.10.159
M3 - Article
C2 - 29101029
AN - SCOPUS:85034419398
SN - 0006-291X
VL - 495
SP - 261
EP - 266
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -