Significance of INHBA expression in human colorectal cancer

Miho Okano; Hirofumi Yamamoto; Hisataka Ohkuma; Yoshihiro Kano; Hirotoshi Kim; Shimpei Nishikawa; Masamitsu Konno; Koichi Kawamoto; Naotsugu Haraguchi; Ichiro Takemasa; Tsunekazu Mizushima; Masataka Ikeda; Takehiko Yokobori; Koshi Mimori; Mitsugu Sekimoto; Yuichiro Doki; Masaki Mori; Hideshi Ishii

doi:10.3892/or.2013.2761

Significance of INHBA expression in human colorectal cancer

Miho Okano, Hirofumi Yamamoto, Hisataka Ohkuma, Yoshihiro Kano, Hirotoshi Kim, Shimpei Nishikawa, Masamitsu Konno, Koichi Kawamoto, Naotsugu Haraguchi, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Takehiko Yokobori, Koshi Mimori, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Surgery

Research output: Contribution to journal › Article › peer-review

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Abstract

Inhibin β A (INHBA) is a member of the transforming growth factor β (TGF-β) superfamily. INHBA expression is associated with several types of human cancers; however, its significance in colorectal cancer (CRC) is not fully understood. INHBA expression was studied in 126 primary CRC samples and 4 CRC cell lines. Cell growth was assessed after inhibition of INHBA e xpression o r a fter e xogenous overexpression of INHBA in CRC tissues. INHBA expression was significantly higher in CRC tissues when compared to that in the corresponding normal tissues (P<0.001). Patients in the high expression group showed a poorer overall survival rate when compared to those in the low expression group (P<0.001); the present study did not evaluate for an independent prognostic factor but showed the significance of lymph node metastasis as an independent prognostic factor. The present study suggests that INHBA is useful as a predictive marker for prognosis in CRC patients.

Original language	English
Pages (from-to)	2903-2908
Number of pages	6
Journal	Oncology reports
Volume	30
Issue number	6
DOIs	https://doi.org/10.3892/or.2013.2761
Publication status	Published - Dec 2013

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/or.2013.2761

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title = "Significance of INHBA expression in human colorectal cancer",

abstract = "Inhibin β A (INHBA) is a member of the transforming growth factor β (TGF-β) superfamily. INHBA expression is associated with several types of human cancers; however, its significance in colorectal cancer (CRC) is not fully understood. INHBA expression was studied in 126 primary CRC samples and 4 CRC cell lines. Cell growth was assessed after inhibition of INHBA e xpression o r a fter e xogenous overexpression of INHBA in CRC tissues. INHBA expression was significantly higher in CRC tissues when compared to that in the corresponding normal tissues (P<0.001). Patients in the high expression group showed a poorer overall survival rate when compared to those in the low expression group (P<0.001); the present study did not evaluate for an independent prognostic factor but showed the significance of lymph node metastasis as an independent prognostic factor. The present study suggests that INHBA is useful as a predictive marker for prognosis in CRC patients.",

author = "Miho Okano and Hirofumi Yamamoto and Hisataka Ohkuma and Yoshihiro Kano and Hirotoshi Kim and Shimpei Nishikawa and Masamitsu Konno and Koichi Kawamoto and Naotsugu Haraguchi and Ichiro Takemasa and Tsunekazu Mizushima and Masataka Ikeda and Takehiko Yokobori and Koshi Mimori and Mitsugu Sekimoto and Yuichiro Doki and Masaki Mori and Hideshi Ishii",

year = "2013",

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doi = "10.3892/or.2013.2761",

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T1 - Significance of INHBA expression in human colorectal cancer

AU - Okano, Miho

AU - Yamamoto, Hirofumi

AU - Ohkuma, Hisataka

AU - Kano, Yoshihiro

AU - Kim, Hirotoshi

AU - Nishikawa, Shimpei

AU - Konno, Masamitsu

AU - Kawamoto, Koichi

AU - Haraguchi, Naotsugu

AU - Takemasa, Ichiro

AU - Mizushima, Tsunekazu

AU - Ikeda, Masataka

AU - Yokobori, Takehiko

AU - Mimori, Koshi

AU - Sekimoto, Mitsugu

AU - Doki, Yuichiro

AU - Mori, Masaki

AU - Ishii, Hideshi

PY - 2013/12

Y1 - 2013/12

N2 - Inhibin β A (INHBA) is a member of the transforming growth factor β (TGF-β) superfamily. INHBA expression is associated with several types of human cancers; however, its significance in colorectal cancer (CRC) is not fully understood. INHBA expression was studied in 126 primary CRC samples and 4 CRC cell lines. Cell growth was assessed after inhibition of INHBA e xpression o r a fter e xogenous overexpression of INHBA in CRC tissues. INHBA expression was significantly higher in CRC tissues when compared to that in the corresponding normal tissues (P<0.001). Patients in the high expression group showed a poorer overall survival rate when compared to those in the low expression group (P<0.001); the present study did not evaluate for an independent prognostic factor but showed the significance of lymph node metastasis as an independent prognostic factor. The present study suggests that INHBA is useful as a predictive marker for prognosis in CRC patients.

AB - Inhibin β A (INHBA) is a member of the transforming growth factor β (TGF-β) superfamily. INHBA expression is associated with several types of human cancers; however, its significance in colorectal cancer (CRC) is not fully understood. INHBA expression was studied in 126 primary CRC samples and 4 CRC cell lines. Cell growth was assessed after inhibition of INHBA e xpression o r a fter e xogenous overexpression of INHBA in CRC tissues. INHBA expression was significantly higher in CRC tissues when compared to that in the corresponding normal tissues (P<0.001). Patients in the high expression group showed a poorer overall survival rate when compared to those in the low expression group (P<0.001); the present study did not evaluate for an independent prognostic factor but showed the significance of lymph node metastasis as an independent prognostic factor. The present study suggests that INHBA is useful as a predictive marker for prognosis in CRC patients.

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EP - 2908

JO - Oncology reports

JF - Oncology reports

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ER -

Significance of INHBA expression in human colorectal cancer

Abstract

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