TY - JOUR
T1 - Signaling crosstalk underlying synergistic induction of astrocyte differentiation by BMPs and IL-6 family of cytokines
AU - Yanagisawa, Makoto
AU - Nakashima, Kinichi
AU - Takizawa, Takumi
AU - Ochiai, Wataru
AU - Arakawa, Hirokazu
AU - Taga, Tetsuya
N1 - Funding Information:
We are very grateful to Ms. Yuko Nakamura and Ms. Yuki Noguchi for their excellent secretarial assistance. We also thank Mr. Ryotaro Watabe, Dr. Atsumi Uemura and Ms. Kaori Kaneko for technical help. This work was supported by Grant-in-Aid from the Ministry of Education, Science, Sports and Culture, Human Frontier Science Program, Ichiro Kanehara Foundation, Inamori Foundation, Kato Memorial Bioscience Foundation, and Naito Foundation.
PY - 2001/2/2
Y1 - 2001/2/2
N2 - We here show that bone morphogenetic protein (BMP) 7 acted in synergy with the distinct type of cytokines, leukemia inhibitory factor (LIF) and interleukin (IL) 6 that are in the IL-6 family, to induce astrocyte differentiation from neuroepithelial cells as assessed by expression of glial fibrillary acidic protein (GFAP). In this synergistic action, transcription factors, Smads and STAT3 (for signal transducer and activator of transcription 3) activated by respective group of cytokines, as well as a transcriptional coactivator p300 were essential. Taken together with our previous finding that the synergistic astrocyte induction by BMP2 and LIF is attributed to the complex formation of Smads and STAT3 bridged by p300, it is conceivable that this complex formation is a mechanism utilized in common by two different types of cytokines belonging to the BMP and IL-6 families in order to synergistically induce astrocyte differentiation.
AB - We here show that bone morphogenetic protein (BMP) 7 acted in synergy with the distinct type of cytokines, leukemia inhibitory factor (LIF) and interleukin (IL) 6 that are in the IL-6 family, to induce astrocyte differentiation from neuroepithelial cells as assessed by expression of glial fibrillary acidic protein (GFAP). In this synergistic action, transcription factors, Smads and STAT3 (for signal transducer and activator of transcription 3) activated by respective group of cytokines, as well as a transcriptional coactivator p300 were essential. Taken together with our previous finding that the synergistic astrocyte induction by BMP2 and LIF is attributed to the complex formation of Smads and STAT3 bridged by p300, it is conceivable that this complex formation is a mechanism utilized in common by two different types of cytokines belonging to the BMP and IL-6 families in order to synergistically induce astrocyte differentiation.
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U2 - 10.1016/S0014-5793(01)02095-6
DO - 10.1016/S0014-5793(01)02095-6
M3 - Article
C2 - 11165238
AN - SCOPUS:0035793462
SN - 0014-5793
VL - 489
SP - 139
EP - 143
JO - FEBS Letters
JF - FEBS Letters
IS - 2-3
ER -