TY - GEN
T1 - Signal pathway analysis with differentiation markers in osteoblasts stimulated by synthetic analogue to bone mineral
AU - Nishikawa, Ryuhei
AU - Anada, Takahisa
AU - Suzuki, Osamu
PY - 2012
Y1 - 2012
N2 - OCTACALCIUM PHOSPHATE (Ca8H2(PO4) 6·5H2O; OCP) is considered as a precursor of biological apatite crystals in bone and tooth in vertebrates. Recent studies have suggested that osteoblastic cell differentiation is enhanced in contact with OCP which is converted into HA and is significantly facilitated in an OCP dose-dependent manner. MAPK signaling is known to be activated in the early stage of the differentiation from bone marrow-derived mesenchymal stem cells into osteoblasts. However, the MAPK signaling is unclear in relation to the stimulatory capacity of OCP in the osteoblastic differentiation. In this study, we investigated the MAPK signaling during the differentiation of bone marrow-derived stromal cell line leading to the late differentiation stage using gene expression analysis.
AB - OCTACALCIUM PHOSPHATE (Ca8H2(PO4) 6·5H2O; OCP) is considered as a precursor of biological apatite crystals in bone and tooth in vertebrates. Recent studies have suggested that osteoblastic cell differentiation is enhanced in contact with OCP which is converted into HA and is significantly facilitated in an OCP dose-dependent manner. MAPK signaling is known to be activated in the early stage of the differentiation from bone marrow-derived mesenchymal stem cells into osteoblasts. However, the MAPK signaling is unclear in relation to the stimulatory capacity of OCP in the osteoblastic differentiation. In this study, we investigated the MAPK signaling during the differentiation of bone marrow-derived stromal cell line leading to the late differentiation stage using gene expression analysis.
UR - http://www.scopus.com/inward/record.url?scp=84876578073&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876578073&partnerID=8YFLogxK
U2 - 10.1109/MHS.2012.6492423
DO - 10.1109/MHS.2012.6492423
M3 - Conference contribution
AN - SCOPUS:84876578073
SN - 9781467348126
T3 - 2012 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2012
SP - 164
EP - 168
BT - 2012 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2012
T2 - 23rd Annual Symposium on Micro-Nano Mechatronics and Human Science, MHS 2012
Y2 - 4 November 2012 through 7 November 2012
ER -