Sick sinus syndrome observed in a patient with cholinesterase deficiency

Shioto Yasuda, Mitsuhiro Fukata, Taku Yokoyama, Takeshi Arita, Keita Odashiro, Toru Maruyama, Yoichiro Hiramoto, Koichi Akashi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


A 58-year-old woman complained of general fatigue and was diagnosed with sick sinus syndrome (SSS) by ambulatory electrocardiogram, which demonstrated sinus arrest at midnight and paroxysmal atrial fibrillation (AF) at nighttime. Since her plasma cholinesterase (ChE) activity had been persistently zero, she was diagnosed with ChE deficiency. She refused permanent pacemaker implantation, and treatment with positive chronotropic drugs is ongoing. A novel association of ChE deficiency with SSS is theoretically possible rather than coincident, considering that ChE plays a key role in cholinergic influences on the sinus node leading to sinus bradyarrhythmia and on the atria, causing vagally mediated AF.

Original languageEnglish
Pages (from-to)809-812
Number of pages4
JournalInternal Medicine
Issue number6
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Internal Medicine


Dive into the research topics of 'Sick sinus syndrome observed in a patient with cholinesterase deficiency'. Together they form a unique fingerprint.

Cite this