TY - JOUR
T1 - Short poly-glutamine repeat in the androgen receptor in New World monkeys
AU - Hiramatsu, Chihiro
AU - Paukner, Annika
AU - Kuroshima, Hika
AU - Fujita, Kazuo
AU - Suomi, Stephen J.
AU - Inoue-Murayama, Miho
N1 - Funding Information:
We are grateful to Hiromi Kobayashi for SYR analyses. We thank Osamu Takenaka and Akiko Takenaka at Primate Research Institute of Kyoto University, staff of Omuta City Zoo and Kyoto City Zoo for providing DNA samples. We also thank the support by the Cooperation Research Program of the Wildlife Research Center, Kyoto University for use of facilities. This study was financially supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Numbers JP25118005 to MI-M, JP10J04395 to CH and the Division of Intramural Research, NICHD Grant Number HD001107-32 .
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/12
Y1 - 2017/12
N2 - The androgen receptor mediates various physiological and developmental functions and is highly conserved in mammals. Although great intraspecific length polymorphisms in poly glutamine (poly-Q) and poly glycine (poly-G) regions of the androgen receptor in humans, apes and several Old World monkeys have been reported, little is known about the characteristics of these regions in New World monkeys. In this study, we surveyed 17 species of New World monkeys and found length polymorphisms in these regions in three species (common squirrel monkeys, tufted capuchin monkeys and owl monkeys). We found that the poly-Q region in New World monkeys is relatively shorter than that in catarrhines (humans, apes and Old World monkeys). In addition, we observed that codon usage for poly-G region in New World monkeys is unique among primates. These results suggest that the length of polymorphic regions in androgen receptor genes have evolved uniquely in New World monkeys.
AB - The androgen receptor mediates various physiological and developmental functions and is highly conserved in mammals. Although great intraspecific length polymorphisms in poly glutamine (poly-Q) and poly glycine (poly-G) regions of the androgen receptor in humans, apes and several Old World monkeys have been reported, little is known about the characteristics of these regions in New World monkeys. In this study, we surveyed 17 species of New World monkeys and found length polymorphisms in these regions in three species (common squirrel monkeys, tufted capuchin monkeys and owl monkeys). We found that the poly-Q region in New World monkeys is relatively shorter than that in catarrhines (humans, apes and Old World monkeys). In addition, we observed that codon usage for poly-G region in New World monkeys is unique among primates. These results suggest that the length of polymorphic regions in androgen receptor genes have evolved uniquely in New World monkeys.
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U2 - 10.1016/j.mgene.2017.08.006
DO - 10.1016/j.mgene.2017.08.006
M3 - Article
AN - SCOPUS:85033667475
SN - 2214-5400
VL - 14
SP - 105
EP - 113
JO - Meta Gene
JF - Meta Gene
ER -