TY - JOUR
T1 - Short communication
T2 - The effect of delayed colostrum feeding on plasma concentrations of glucagon-like peptide 1 and 2 in newborn calves
AU - Inabu, Y.
AU - Fischer, A.
AU - Song, Y.
AU - Guan, L. L.
AU - Oba, M.
AU - Steele, M. A.
AU - Sugino, T.
N1 - Funding Information:
The authors thank the funding support provided by Alberta Livestock and Meat Agency Ltd. (Edmonton, AB, Canada), Alberta Milk (Edmonton, AB, Canada), The Saskatoon Colostrum Co. Ltd. (Saskatoon, SK, Canada), and the Natural Sciences and Engineering Research Council of Canada (Moncton, NB, Canada). The authors also thank the staff of the Dairy Research and Technology Centre (University of Alberta) for their assistance with the animal experiment.
Publisher Copyright:
© 2018 American Dairy Science Association
PY - 2018/7
Y1 - 2018/7
N2 - Glucagon-like peptide (GLP)-1 is involved in glucose homeostasis via its role in stimulating insulin secretion, whereas GLP-2 increases mucosal growth of the small intestine. To our knowledge, the effect of delayed colostrum feeding on plasma GLP-1 and GLP-2 in neonatal calves has not been evaluated. To investigate the effect of delayed colostrum feeding on plasma concentrations of GLP-1 and GLP-2 in newborn calves, we randomly assigned 27 Holstein bull calves to 1 of 3 treatment groups: those fed colostrum within 1 h after birth (control), 6 h after birth (6H), and 12 h after birth (12H; n = 9 for each treatment). Blood samples were obtained before the colostrum feeding and every 3 h after each colostrum feeding for a 36-h period, and plasma concentrations of GLP-1, GLP-2, insulin, and glucose were measured. Plasma GLP-1 concentration at 12 h after colostrum feeding was lower in 12H than in control calves. In addition, plasma insulin concentration was lower in the 6H and 12H calves than in the controls. Plasma glucose and GLP-2 concentrations were, however, not affected by treatment. These results indicate that delayed colostrum feeding can decrease plasma GLP-1 and insulin concentrations without affecting glucose or GLP-2 concentration.
AB - Glucagon-like peptide (GLP)-1 is involved in glucose homeostasis via its role in stimulating insulin secretion, whereas GLP-2 increases mucosal growth of the small intestine. To our knowledge, the effect of delayed colostrum feeding on plasma GLP-1 and GLP-2 in neonatal calves has not been evaluated. To investigate the effect of delayed colostrum feeding on plasma concentrations of GLP-1 and GLP-2 in newborn calves, we randomly assigned 27 Holstein bull calves to 1 of 3 treatment groups: those fed colostrum within 1 h after birth (control), 6 h after birth (6H), and 12 h after birth (12H; n = 9 for each treatment). Blood samples were obtained before the colostrum feeding and every 3 h after each colostrum feeding for a 36-h period, and plasma concentrations of GLP-1, GLP-2, insulin, and glucose were measured. Plasma GLP-1 concentration at 12 h after colostrum feeding was lower in 12H than in control calves. In addition, plasma insulin concentration was lower in the 6H and 12H calves than in the controls. Plasma glucose and GLP-2 concentrations were, however, not affected by treatment. These results indicate that delayed colostrum feeding can decrease plasma GLP-1 and insulin concentrations without affecting glucose or GLP-2 concentration.
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U2 - 10.3168/jds.2018-14412
DO - 10.3168/jds.2018-14412
M3 - Article
C2 - 29680641
AN - SCOPUS:85045925524
SN - 0022-0302
VL - 101
SP - 6627
EP - 6631
JO - Journal of Dairy Science
JF - Journal of Dairy Science
IS - 7
ER -