@article{93f78d1f529145039645cee7aa00d416,
title = "SF3B4 plays an oncogenic role in esophageal squamous cell carcinoma",
abstract = "Background/Aim: The spliceosome pathway, including Splicing Factor 3b Subunit 4 (SF3B4), plays an important role in carcinogenesis and progression in various cancers; however, the clinical relevance of SF3B4 in esophageal squamous cell carcinoma (ESCC) remains unknown. Patients and Methods: SF3B4 expression was evaluated by real-time reverse transcription polymerase chain reaction in 80 ESCC patients. In order to explore the mechanism of SF3B4 in ESCC, the mRNA expression and copy number of SF3B4 were obtained from TCGA and we also implemented gene set enrichment analysis (GSEA). Results: The high SF3B4 expression group (n=33) showed significantly more lymphatic permeation and poorer prognosis than the low SF3B4 expression group (n=47). GSEA revealed that high SF3B4 expression was correlated with genes associated with the transcription factor E2F and the G2/M checkpoint. SF3B4 expression was positively correlated with SF3B4 DNA copy number. Conclusion: Over-expression of SF3B4 may play a crucial role in the lymphatic progression of ESCC.",
author = "Shinya Kidogami and Tomohiro Iguchi and Kuniaki Sato and Yukihiro Yoshikawa and Quingjang Hu and Sho Nambara and Hisateru Komatsu and Masami Ueda and Yosuke Kuroda and Takaaki Masuda and Masaki Mori and Yuichiro Doki and Koshi Mimori",
note = "Funding Information: This work was supported by the following grants and foundations: Grants-in-Aid for Scientific Research of MEXT (24008081, 25430111, 25461953, 25861199, 25861200, 24592005 and 21229015); Funding Program for Next Generation World-Leading Researchers (LS094); Grants-in-Aid for Scientific Research on Innovative Areas of MEXT “Systems Cancer Research” (4201); The MEXT Strategic Programs on Innovative Research “Supercomputational Life Science.” This research used computational resources of the K computer provided by the RIKEN Advanced Institute for Computational Science through the HPCI System Research project (Project ID: hp140230). Computation time was also provided by the Supercomputer System, Human Genome Center, Institute of Medical Science, University of Tokyo (http://sc.hgc.jp/shirokane.html). The OITA Cancer Research Foundation 2014. Grant-in-Aid for Scientific Research of Ministry of Health, Labor and Welfare (MHLW) (14524362 and 14525288). Clinical samples and corresponding clinical information were provided by Oita Red Cross Hospital (Oita, Japan), Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital (Hiroshima, Japan) and Iizuka Hospital (Fukuoka, Japan). The Authors appreciate the technical support of Ms. Kazumi Oda, Michiko Kasagi, Sachiko Sakuma and Tomoko Kawano. Publisher Copyright: {\textcopyright} 2020 International Institute of Anticancer Research. All rights reserved.",
year = "2020",
month = may,
doi = "10.21873/anticanres.14272",
language = "English",
volume = "40",
pages = "2941--2946",
journal = "Anticancer research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "5",
}
