TY - JOUR
T1 - Sex hormone and neuroendocrine aspects of the metabolic syndrome.
AU - Nawata, Hajime
AU - Watanabe, Tetsuhiro
AU - Yanase, Toshihiko
AU - Nomura, Masatoshi
AU - Ashida, Kenji
AU - Min, Liu
AU - Fan, Wuqiand
PY - 2010
Y1 - 2010
N2 - We discuss the recent advances in the knowledge that the sex steroids testosterone (T), estradiol and dehydroepiandrosterone sulphate (DHEA-S) are involved in the development of visceral obesity and of the metabolic syndrome. Cross talk between leptin and the androgen receptor (AR) in the hypothalamus as well as the peripheral conversion of DHEA and T to estrone, estradiol and dihydrotestosterone (DHT) in adipocytes and hepatocytes play important roles in the metabolic syndrome in men. Finally, we discuss the development of new drugs, selective AR modulators, for treating the metabolic syndrome in men.
AB - We discuss the recent advances in the knowledge that the sex steroids testosterone (T), estradiol and dehydroepiandrosterone sulphate (DHEA-S) are involved in the development of visceral obesity and of the metabolic syndrome. Cross talk between leptin and the androgen receptor (AR) in the hypothalamus as well as the peripheral conversion of DHEA and T to estrone, estradiol and dihydrotestosterone (DHT) in adipocytes and hepatocytes play important roles in the metabolic syndrome in men. Finally, we discuss the development of new drugs, selective AR modulators, for treating the metabolic syndrome in men.
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U2 - 10.1016/s0079-6123(10)82007-2
DO - 10.1016/s0079-6123(10)82007-2
M3 - Article
C2 - 20541665
AN - SCOPUS:77956633487
SN - 0079-6123
VL - 182
SP - 175
EP - 187
JO - Progress in brain research
JF - Progress in brain research
ER -
