Serum25-hydroxyvitamin D and markers of insulin resistance in a Japanese working population

N. M. Pham, S. Akter, K. Kurotani, A. Nanri, M. Sato, H. Hayabuchi, K. Yasuda, T. Mizoue

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Background/Objectives: The association between vitamin D status and insulin resistance (IR) has been less studied among Asians, and it remains elusive whether calcium could modify such an association. We examined the association of serum25-hydroxyvitamin D (25(OH)D) concentrations with IR markers and the potential effect modification by calcium intake among a Japanese population.Subjects/Methods:The authors analyzed data (n=494) from a cross-sectional survey conducted in 2009 among a Japanese working population aged 20-68 years. Fasting serum25(OH)D and insulin, as well as fasting plasma glucose were determined, and homeostatic model assessment of IR (HOMA-IR) was calculated. Calcium intake was assessed using a validated diet history questionnaire. Multiple linear regression was done with adjustment of potential confounding variables.Results:Fasting insulin and HOMA-IR were significantly inversely associated with 25(OH)D concentration across quartiles of 25(OH)D after fully adjusting for covariates (P trend= 0.04 and 0.02, respectively). Across clinically relevant categories of 25(OH)D, compared with participants in the vitamin D sufficiency group, those in the vitamin D insufficiency group had a 5% higher HOMA-IR score, and those in the hypovitaminosis D group had an 18% higher HOMA-IR score (P trend= 0.01). In an analysis by calcium intake, the HOMA-IR score was highest among participants with both a low calcium intake and lowest 25(OH)D concentrations, with significant inverse trend being observed in the group with lower calcium intake (P trend= 0.02).Conclusions:Our findings suggest that low vitamin D status is associated with IR among Japanese adults.

Original languageEnglish
Pages (from-to)1323-1328
Number of pages6
JournalEuropean Journal of Clinical Nutrition
Issue number12
Publication statusPublished - Dec 2012

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


Dive into the research topics of 'Serum25-hydroxyvitamin D and markers of insulin resistance in a Japanese working population'. Together they form a unique fingerprint.

Cite this