Serum interleukin-6 in schizophrenic patients

Futoshi Shintani, Shigenobu Kanba, Naoko Maruo, Toshio Nakaki, Masashi Nibuya, Eiji Suzuki, Norihisa Kinoshita, Gohei Yagi

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)


We examined serum interleukin-6 (IL-6) in 90 schizophrenic patients in remission and 90 normal controls using enzyme-linked immuno-sorbent assay (ELISA). We found a significant difference in variation between the schizophrenic and the control groups (F = 10.9, P < .002). The difference in distribution was also statistically significant by Kolmogorov-Smirnov (chi-square = 45.0, P < .001). Eight patients had aberrantly high serum levels of interleukin-6. Since the higher levels of IL-6 are characteristically found in several autoimmune disorders, our finding suggests a link between schizophrenia and immune response, which could be either autoimmune or a process induced by reactivation of viruses.

Original languageEnglish
Pages (from-to)661-664
Number of pages4
JournalLife Sciences
Issue number9
Publication statusPublished - 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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