Serum interleukin-6 in schizophrenic patients

Futoshi Shintani; Shigenobu Kanba; Naoko Maruo; Toshio Nakaki; Masashi Nibuya; Eiji Suzuki; Norihisa Kinoshita; Gohei Yagi

doi:10.1016/0024-3205(91)90112-O

Serum interleukin-6 in schizophrenic patients

Futoshi Shintani, Shigenobu Kanba, Naoko Maruo, Toshio Nakaki, Masashi Nibuya, Eiji Suzuki, Norihisa Kinoshita, Gohei Yagi

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

We examined serum interleukin-6 (IL-6) in 90 schizophrenic patients in remission and 90 normal controls using enzyme-linked immuno-sorbent assay (ELISA). We found a significant difference in variation between the schizophrenic and the control groups (F = 10.9, P < .002). The difference in distribution was also statistically significant by Kolmogorov-Smirnov (chi-square = 45.0, P < .001). Eight patients had aberrantly high serum levels of interleukin-6. Since the higher levels of IL-6 are characteristically found in several autoimmune disorders, our finding suggests a link between schizophrenia and immune response, which could be either autoimmune or a process induced by reactivation of viruses.

Original language	English
Pages (from-to)	661-664
Number of pages	4
Journal	Life Sciences
Volume	49
Issue number	9
DOIs	https://doi.org/10.1016/0024-3205(91)90112-O
Publication status	Published - 1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry,Genetics and Molecular Biology

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10.1016/0024-3205(91)90112-O

Cite this

@article{95cba1203cac4efba4c8072bde422587,

title = "Serum interleukin-6 in schizophrenic patients",

abstract = "We examined serum interleukin-6 (IL-6) in 90 schizophrenic patients in remission and 90 normal controls using enzyme-linked immuno-sorbent assay (ELISA). We found a significant difference in variation between the schizophrenic and the control groups (F = 10.9, P < .002). The difference in distribution was also statistically significant by Kolmogorov-Smirnov (chi-square = 45.0, P < .001). Eight patients had aberrantly high serum levels of interleukin-6. Since the higher levels of IL-6 are characteristically found in several autoimmune disorders, our finding suggests a link between schizophrenia and immune response, which could be either autoimmune or a process induced by reactivation of viruses.",

author = "Futoshi Shintani and Shigenobu Kanba and Naoko Maruo and Toshio Nakaki and Masashi Nibuya and Eiji Suzuki and Norihisa Kinoshita and Gohei Yagi",

note = "Funding Information: We acknowledge Drs. Nobuo Ohtsuka and Fumio Saito for encouragement, and Miss. Hiroko Saito and Mr. Takayuki Okaniwa for excellent technical assistance. This work was in part supported by Ohme Keiyu Hospital Research Grant.",

year = "1991",

doi = "10.1016/0024-3205(91)90112-O",

language = "English",

volume = "49",

pages = "661--664",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "9",

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T1 - Serum interleukin-6 in schizophrenic patients

AU - Shintani, Futoshi

AU - Kanba, Shigenobu

AU - Maruo, Naoko

AU - Nakaki, Toshio

AU - Nibuya, Masashi

AU - Suzuki, Eiji

AU - Kinoshita, Norihisa

AU - Yagi, Gohei

N1 - Funding Information: We acknowledge Drs. Nobuo Ohtsuka and Fumio Saito for encouragement, and Miss. Hiroko Saito and Mr. Takayuki Okaniwa for excellent technical assistance. This work was in part supported by Ohme Keiyu Hospital Research Grant.

PY - 1991

Y1 - 1991

N2 - We examined serum interleukin-6 (IL-6) in 90 schizophrenic patients in remission and 90 normal controls using enzyme-linked immuno-sorbent assay (ELISA). We found a significant difference in variation between the schizophrenic and the control groups (F = 10.9, P < .002). The difference in distribution was also statistically significant by Kolmogorov-Smirnov (chi-square = 45.0, P < .001). Eight patients had aberrantly high serum levels of interleukin-6. Since the higher levels of IL-6 are characteristically found in several autoimmune disorders, our finding suggests a link between schizophrenia and immune response, which could be either autoimmune or a process induced by reactivation of viruses.

AB - We examined serum interleukin-6 (IL-6) in 90 schizophrenic patients in remission and 90 normal controls using enzyme-linked immuno-sorbent assay (ELISA). We found a significant difference in variation between the schizophrenic and the control groups (F = 10.9, P < .002). The difference in distribution was also statistically significant by Kolmogorov-Smirnov (chi-square = 45.0, P < .001). Eight patients had aberrantly high serum levels of interleukin-6. Since the higher levels of IL-6 are characteristically found in several autoimmune disorders, our finding suggests a link between schizophrenia and immune response, which could be either autoimmune or a process induced by reactivation of viruses.

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VL - 49

SP - 661

EP - 664

JO - Life Sciences

JF - Life Sciences

IS - 9

ER -

Serum interleukin-6 in schizophrenic patients

Abstract

All Science Journal Classification (ASJC) codes

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