TY - JOUR
T1 - Serum high-sensitivity C-reactive protein levels and the development of atrial fibrillation in a general japanese population - The hisayama study
AU - Yoshikawa, Tomoko
AU - Hata, Jun
AU - Sakata, Satoko
AU - Nagata, Takuya
AU - Hirakawa, Yoichiro
AU - Hirooka, Yoshitaka
AU - Tsutsui, Hiroyuki
AU - Kitazono, Takanari
AU - Ninomiya, Toshiharu
N1 - Funding Information:
This study was supported, in part, by a Grant-in-Aid for Scientific Research (A) (JP16H02692), (B) (JP17H04126, JP18H02737 and JP19H03863) and (C) (JP18K07565, JP18K09412, JP19K07890, JP20K10503, and JP20K11020), Grant-in-Aid for Early-Career Scientists (JP18K17925), and a Grant-in-Aid for Research Activity Start-up (JP19K23971) from the Ministry of Education, Culture, Sports, Science and Technology of Japan; by a Health and Labour Sciences Research Grant from the Ministry of Health, Labour and Welfare of Japan (20FA1002); and by the Japan Agency for Medical Research and Development (JP19ek0210082, JP19ek0210083, JP20dk0207025, JP20km0405202, JP20fk0108075).
Funding Information:
This study was supported, in part, by a Grant-in-Aid for Scientific Research (A) (JP16H02692), (B) (JP17H04126, JP18H02737 and JP19H03863) and (C) (JP18K07565, JP18K09412, JP19K07890, JP20K10503, and JP20K11020), Grant-in-Aid for Early-Career Scientists (JP18K17925), and a Grant-in-Aid for Research Activity Startup (JP19K23971) from the Ministry of Education, Culture, Sports, Science and Technology of Japan; by a Health and Labour Sciences Research Grant from the Ministry of Health, Labour and Welfare of Japan (20FA1002); and by the Japan Agency for Medical Research and Development (JP19ek0210082, JP19ek0210083, JP20dk0207025, JP20 km0405202, JP20fk0108075). We thank the staff of the Division of Health and Welfare of Hisayama for their cooperation in this study. The statistical analyses were carried out using the computer resources offered under the category of General Projects by the Research Institute for Information Technology, Kyushu University.
Publisher Copyright:
© 2021 Japanese Circulation Society. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Background: Atrial fibrillation (AF) is a common arrhythmia in the elderly, and causes complications such as cardioembolic stroke. Serum high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, has been reported to be a risk factor for developing AF in Western countries. However, few community-based studies have examined this issue in general Asian populations. Methods and Results: A total of 2,510 community-dwelling Japanese participants aged ≥40 years without a history of AF were divided into 4 groups according to the sex-specific quartiles of serum hs-CRP concentrations (Q1, lowest and Q4, highest) and followed up for 24 years. The hazard ratios and their 95% confidence intervals for the development of AF were estimated using a Cox proportional hazards model. During the follow up, 234 subjects developed AF. The risk of AF increased significantly with elevating serum hs-CRP levels after adjustment for potential confounding factors (hazard ratio [95% confidence interval], Q1, 1.00 [reference]; Q2, 1.26 [0.83.1.92]; Q3, 1.77 [1.18.2.66]; and Q4, 1.89 [1.24.2.86]; P for trend <0.001). Conclusions: The study findings suggest that elevated serum hs-CRP levels are an independent risk factor for the development of AF in a general Japanese population.
AB - Background: Atrial fibrillation (AF) is a common arrhythmia in the elderly, and causes complications such as cardioembolic stroke. Serum high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, has been reported to be a risk factor for developing AF in Western countries. However, few community-based studies have examined this issue in general Asian populations. Methods and Results: A total of 2,510 community-dwelling Japanese participants aged ≥40 years without a history of AF were divided into 4 groups according to the sex-specific quartiles of serum hs-CRP concentrations (Q1, lowest and Q4, highest) and followed up for 24 years. The hazard ratios and their 95% confidence intervals for the development of AF were estimated using a Cox proportional hazards model. During the follow up, 234 subjects developed AF. The risk of AF increased significantly with elevating serum hs-CRP levels after adjustment for potential confounding factors (hazard ratio [95% confidence interval], Q1, 1.00 [reference]; Q2, 1.26 [0.83.1.92]; Q3, 1.77 [1.18.2.66]; and Q4, 1.89 [1.24.2.86]; P for trend <0.001). Conclusions: The study findings suggest that elevated serum hs-CRP levels are an independent risk factor for the development of AF in a general Japanese population.
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U2 - 10.1253/circj.CJ-20-0751
DO - 10.1253/circj.CJ-20-0751
M3 - Article
C2 - 33597325
AN - SCOPUS:85110751079
SN - 1346-9843
VL - 85
SP - 1365
EP - 1372
JO - Circulation Journal
JF - Circulation Journal
IS - 8
ER -