Serum concentration of the soluble interleukin-2 receptor for monitoring acute graft-versus-host disease

Toshihiro Miyamoto, K. Akashi, S. Hayashi, H. Gondo, M. Murakawa, K. Tanimoto, M. Harada, Y. Niho

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Soluble interleukin-2 receptors (sIL-2R) are elevated in various disorders involving the activation of T cells. We measured serial serum concentrations of sIL-2R in 30 patients receiving allogeneic BMT to evaluate the usefulness of sIL-2R as a parameter for acute GVHD. In the 17 patients who developed acute GVHD, the sIL-2R concentration rose significantly on day 3 following transplantation, preceding the occurrence of acute GVHD. This change was not seen in the 13 patients without acute GVHD. The serum concentration of sIL-2R decreased as the acute GVHD subsided. The peak concentration of serum sIL-2R correlated with the severity of the acute GVHD. Simultaneous measurement of tumor necrosis factor α (TNFα) showed a significant rise in patients with acute GVHD, that became evident earlier than the sIL-2R elevation. TNFα concentrations also decreased following treatment of the acute GVHD. However, significant rises in TNFα were also seen in the early phase of allogeneic BMT in patients who did not develop acute GVHD. Our data suggest that the serum concentrations of sIL-2R as well as TNFα might reflect the severity of acute GVHD, and that the serum sIL-2R concentration might be a sensitive and practical indicator for acute GVHD.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalBone Marrow Transplantation
Issue number2
Publication statusPublished - Feb 1996

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation


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