Serial histologic evaluation of multiple primary squamous cell carcinomas of the esophagus

Hiroyuki Kuwano, Shinji Ohno, Hiroyuki Matsuda, Masaki Mori, Keizo Sugimachi

Research output: Contribution to journalArticlepeer-review

102 Citations (Scopus)


A review of data on 205 patients with esophageal squamous cell carcinoma who underwent subtotal esophagectomy revealed 30 cases (14.6%) and 32 lesions with multiple primary squamous cell carcinomas. The incidence of this multiplicity was 11.7% and 25.6% in those with and without preoperative irradiation treatment, respectively. Among the 32 second lesions, there were 17 intraepithelial carcinomas, eight restricted to the mucosa, five invading the submucosa, one invading down to the proper muscular layer, and one involving the entire thickness of the esophageal wall. These second lesions were in the relatively early stage. Moreover, incidence of the coexistence of intraepithelial carcinoma contiguous to the main lesion was 42.1% and 100.0% in those with multiple cancers, with and without preoperative irradiation, respectively. The values were 7.6% and 53.1% in patients with a solitary carcinoma, respectively. These findings show the close relationship between multiplicity and intraepithelial carcinoma contiguous to the main lesion, and support the concept of muiticentric or field carcinogenesis of esophageal squamous cell carcinoma.

Original languageEnglish
Pages (from-to)1635-1638
Number of pages4
Issue number8
Publication statusPublished - Apr 15 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


Dive into the research topics of 'Serial histologic evaluation of multiple primary squamous cell carcinomas of the esophagus'. Together they form a unique fingerprint.

Cite this