Sequence and expression of transcripts of the human T-cell receptor β- chain genes

Yasunobu Yoshikai; Demetri Anatoniou; Stephen P. Clark; Yusuke Yanagi; Robert Sangster; Peter Van Den Elsen; Cox Terhorst; Tak W. Mak

doi:10.1038/312521a0

Sequence and expression of transcripts of the human T-cell receptor β- chain genes

Yasunobu Yoshikai, Demetri Anatoniou, Stephen P. Clark, Yusuke Yanagi, Robert Sangster, Peter Van Den Elsen, Cox Terhorst, Tak W. Mak

Research output: Contribution to journal › Article › peer-review

327 Citations (Scopus)

Abstract

T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor β-chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains V, J and one of the two C region sequences, but does not always contain D sequences. A 1.0-kb mRNA, found mainly in immature T cells, does not contain V sequences and can result from transcription that initiates upstream from an unrearranged J element.

Original language	English
Pages (from-to)	521-524
Number of pages	4
Journal	Nature
Volume	312
Issue number	5994
DOIs	https://doi.org/10.1038/312521a0
Publication status	Published - 1984
Externally published	Yes

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10.1038/312521a0

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title = "Sequence and expression of transcripts of the human T-cell receptor β- chain genes",

abstract = "T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor β-chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains V, J and one of the two C region sequences, but does not always contain D sequences. A 1.0-kb mRNA, found mainly in immature T cells, does not contain V sequences and can result from transcription that initiates upstream from an unrearranged J element.",

author = "Yasunobu Yoshikai and Demetri Anatoniou and Clark, {Stephen P.} and Yusuke Yanagi and Robert Sangster and {Van Den Elsen}, Peter and Cox Terhorst and Mak, {Tak W.}",

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doi = "10.1038/312521a0",

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journal = "Nature",

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T1 - Sequence and expression of transcripts of the human T-cell receptor β- chain genes

AU - Yoshikai, Yasunobu

AU - Anatoniou, Demetri

AU - Clark, Stephen P.

AU - Yanagi, Yusuke

AU - Sangster, Robert

AU - Van Den Elsen, Peter

AU - Terhorst, Cox

AU - Mak, Tak W.

PY - 1984

Y1 - 1984

N2 - T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor β-chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains V, J and one of the two C region sequences, but does not always contain D sequences. A 1.0-kb mRNA, found mainly in immature T cells, does not contain V sequences and can result from transcription that initiates upstream from an unrearranged J element.

AB - T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor β-chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains V, J and one of the two C region sequences, but does not always contain D sequences. A 1.0-kb mRNA, found mainly in immature T cells, does not contain V sequences and can result from transcription that initiates upstream from an unrearranged J element.

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DO - 10.1038/312521a0

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SP - 521

EP - 524

JO - Nature

JF - Nature

IS - 5994

ER -

Sequence and expression of transcripts of the human T-cell receptor β- chain genes

Abstract

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