TY - GEN
T1 - Separation of viable cells using deterministic lateral displacement microfluidic device
AU - Tottori, Naotomo
AU - Park, Jongho
AU - Yanagida, Yasuko
AU - Hatsuzawa, Takeshi
PY - 2015/1/1
Y1 - 2015/1/1
N2 - We report the first use of deterministic lateral displacement (DLD) microfluidic device for label-free separation of viable cells from nonviable cells. Cells in apoptosis status are physically smaller than viable cells. We focused on this phenomenon and have demonstrated the separation of viable cells from nonviable cells using DLD method, which can separate particles based on their sizes continuously without any labeling and external energy sources. We succeeded in the removal of 66.9% nonviable cells and also enrichment of viable cells.
AB - We report the first use of deterministic lateral displacement (DLD) microfluidic device for label-free separation of viable cells from nonviable cells. Cells in apoptosis status are physically smaller than viable cells. We focused on this phenomenon and have demonstrated the separation of viable cells from nonviable cells using DLD method, which can separate particles based on their sizes continuously without any labeling and external energy sources. We succeeded in the removal of 66.9% nonviable cells and also enrichment of viable cells.
UR - http://www.scopus.com/inward/record.url?scp=84983242590&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983242590&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84983242590
T3 - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 404
EP - 406
BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Y2 - 25 October 2015 through 29 October 2015
ER -