Separation of endo-cyclic 2-methacryloyloxyethyl choline phosphate by anion exchange approach

Masaru Mukai; Yuji Higaki; Tomoyasu Hirai; Atsushi Takahara

doi:10.1246/cl.180787

Separation of endo-cyclic 2-methacryloyloxyethyl choline phosphate by anion exchange approach

Masaru Mukai, Yuji Higaki, Tomoyasu Hirai, Atsushi Takahara

Department of Applied Molecular Chemistry

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

2-Methacryloyloxyethyl choline phosphate (MCP) was synthesized by a ring-opening reaction of cyclic phosphates with 2-(dimethylaminoethyl methacrylate). The crude MCP consisted of an endo-cyclic desired product and an exo-cyclic byproduct. The exo-cyclic byproduct was completely removed by anion-exchange and subsequent open-column chromatography. We successfully obtained pure MCP without the exo-cyclic byproduct, and synthesized MCP polymers by free radical polymerization.

Original language	English
Pages (from-to)	1509-1511
Number of pages	3
Journal	Chemistry Letters
Volume	47
Issue number	12
DOIs	https://doi.org/10.1246/cl.180787
Publication status	Published - 2018

All Science Journal Classification (ASJC) codes

General Chemistry

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10.1246/cl.180787

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title = "Separation of endo-cyclic 2-methacryloyloxyethyl choline phosphate by anion exchange approach",

abstract = "2-Methacryloyloxyethyl choline phosphate (MCP) was synthesized by a ring-opening reaction of cyclic phosphates with 2-(dimethylaminoethyl methacrylate). The crude MCP consisted of an endo-cyclic desired product and an exo-cyclic byproduct. The exo-cyclic byproduct was completely removed by anion-exchange and subsequent open-column chromatography. We successfully obtained pure MCP without the exo-cyclic byproduct, and synthesized MCP polymers by free radical polymerization.",

author = "Masaru Mukai and Yuji Higaki and Tomoyasu Hirai and Atsushi Takahara",

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year = "2018",

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journal = "Chemistry Letters",

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T1 - Separation of endo-cyclic 2-methacryloyloxyethyl choline phosphate by anion exchange approach

AU - Mukai, Masaru

AU - Higaki, Yuji

AU - Hirai, Tomoyasu

AU - Takahara, Atsushi

PY - 2018

Y1 - 2018

N2 - 2-Methacryloyloxyethyl choline phosphate (MCP) was synthesized by a ring-opening reaction of cyclic phosphates with 2-(dimethylaminoethyl methacrylate). The crude MCP consisted of an endo-cyclic desired product and an exo-cyclic byproduct. The exo-cyclic byproduct was completely removed by anion-exchange and subsequent open-column chromatography. We successfully obtained pure MCP without the exo-cyclic byproduct, and synthesized MCP polymers by free radical polymerization.

AB - 2-Methacryloyloxyethyl choline phosphate (MCP) was synthesized by a ring-opening reaction of cyclic phosphates with 2-(dimethylaminoethyl methacrylate). The crude MCP consisted of an endo-cyclic desired product and an exo-cyclic byproduct. The exo-cyclic byproduct was completely removed by anion-exchange and subsequent open-column chromatography. We successfully obtained pure MCP without the exo-cyclic byproduct, and synthesized MCP polymers by free radical polymerization.

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JO - Chemistry Letters

JF - Chemistry Letters

IS - 12

ER -

Separation of endo-cyclic 2-methacryloyloxyethyl choline phosphate by anion exchange approach

Abstract

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