Self‐reactive T cells are activated by the 65‐kDa mycobacterial heat‐shock protein in neonatally thymectomized mice

Akinori Iwasaki, Yasunobu Yoshikai, Hiroyuki Yuuki, Hiroaki Takimoto, Kikuo Nomoto

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

To elucidate the mechanism of autoimmune disease in neonatally thymectomized (NTX) mice, we have investigated the responsiveness of the self‐reactive T cells which have not undergone clonal deletion in such animals. Consistent with a recent report (Yuuki et al., Eur. J. Immunol. 1990. 20: 1475), T cells bearing Vβ11‐gene products capable of recognizing I‐E‐encoded molecules were readily detected in the mature T cell pool of NTX BALB/c (I‐Ed, Mls‐2a) mice. The Vβ11‐bearing T cells in NTX mice expressed interleukin 2 receptors and responded normally to signals delivered through the T cell receptor. Notably, these T cells in NTX mice proliferated significantly after culture with the 65‐kDa mycobacterial heat‐shock protein, whose amino acid sequence is highly homologous to that in eukaryotes. These results suggest that self‐reactive T cells in NTX mice may be activated by heat‐shock proteins derived from various pathogens and/or stressed autologous cells, resulting in the development of autoimmune diseases in such animals.

Original languageEnglish
Pages (from-to)597-603
Number of pages7
JournalEuropean Journal of Immunology
Volume21
Issue number3
DOIs
Publication statusPublished - Mar 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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