TY - JOUR
T1 - Self-Assembled Biradical Ureabenzene Nanoparticles for Magnetic Resonance Imaging
AU - Morishita, Kosuke
AU - Ueki, Shoji
AU - Fuchi, Yasufumi
AU - Murayama, Shuhei
AU - Kaneko, Tomoyo
AU - Narita, Nozomi
AU - Kobayashi, Shigeki
AU - Hirai, Go
AU - Aoki, Ichio
AU - Karasawa, Satoru
N1 - Publisher Copyright:
Copyright © 2018 American Chemical Society.
PY - 2018/12/28
Y1 - 2018/12/28
N2 - As part of a series of investigations related to the construction of metal-free magnetic resonance imaging (MRI) contrast agents as alternatives to gadolinium agents, water-soluble biradicals, denoted as 1-AMP and 2-HEG, were prepared, in which two stable radicals were introduced to a ureabenzene framework. We found that 1-AMP possessed an amphiphilic side chain that consisted of an alkyl group and a hexaethylene glycol (HEG) chain, whereas 2-HEG possessed only an HEG chain. Accordingly, the biradicals showed self-assembly behavior due to multiple intermolecular interactions through which nanoparticles were formed in a water solution. Magnetic interaction took place in both biradicals, and the estimated interaction strength was J = 5.4 mT. Through MRI measurement, the water proton relaxivities, r1, were estimated to be 0.12 and 0.41 mM-1 s-1 for 1-AMP and 2-HEG, respectively; in other words, the r1 value for 2-HEG was approximately twice as high as that of monoradical-based contrast agents. ©
AB - As part of a series of investigations related to the construction of metal-free magnetic resonance imaging (MRI) contrast agents as alternatives to gadolinium agents, water-soluble biradicals, denoted as 1-AMP and 2-HEG, were prepared, in which two stable radicals were introduced to a ureabenzene framework. We found that 1-AMP possessed an amphiphilic side chain that consisted of an alkyl group and a hexaethylene glycol (HEG) chain, whereas 2-HEG possessed only an HEG chain. Accordingly, the biradicals showed self-assembly behavior due to multiple intermolecular interactions through which nanoparticles were formed in a water solution. Magnetic interaction took place in both biradicals, and the estimated interaction strength was J = 5.4 mT. Through MRI measurement, the water proton relaxivities, r1, were estimated to be 0.12 and 0.41 mM-1 s-1 for 1-AMP and 2-HEG, respectively; in other words, the r1 value for 2-HEG was approximately twice as high as that of monoradical-based contrast agents. ©
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U2 - 10.1021/acsanm.8b01774
DO - 10.1021/acsanm.8b01774
M3 - Article
AN - SCOPUS:85075680022
SN - 2574-0970
VL - 1
SP - 6967
EP - 6975
JO - ACS Applied Nano Materials
JF - ACS Applied Nano Materials
IS - 12
ER -