Self and nonself recognition through C-type lectin receptor, Mincle

Yasunobu Miyake, Eri Ishikawa, Tetsuaki Ishikawa, Sho Yamasaki

    Research output: Contribution to journalReview articlepeer-review

    37 Citations (Scopus)


    Mincle (also called as Clec4e or Clecsf9) is a C-type lectin receptor expressed in activated macrophages. Recently, we have reported that Mincle transduces the activation signals through ITAM-containing adaptor protein, FcRγ and induces the secretion of inflammatory cytokines. Furthermore, we and other groups have identified that Mincle recognizes a wide variety of ligands such as damaged cells, fungus, yeast and mycobacteria. These results indicate that Mincle acts as a multi-task danger receptor for both self and nonself ligands. This review summarizes the recent discoveries about the ligands and immunological roles of Mincle.

    Original languageEnglish
    Pages (from-to)310-313
    Number of pages4
    JournalSelf/Nonself - Immune Recognition and Signaling
    Issue number4
    Publication statusPublished - Oct 2010

    All Science Journal Classification (ASJC) codes

    • Immunology
    • Immunology and Microbiology (miscellaneous)


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