Scopoletin: An inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei

Tai Hyun Kang; Hyun Ock Pae; Sei Joon Jeong; Ji Chang Yoo; Byung Min Choi; Chang Duk Jun; Hun Taeg Chung; T. Miyamoto; R. Higuchi; Youn Chul Kim

doi:10.1055/s-1999-14014

Scopoletin: An inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei

Tai Hyun Kang, Hyun Ock Pae, Sei Joon Jeong, Ji Chang Yoo, Byung Min Choi, Chang Duk Jun, Hun Taeg Chung, T. Miyamoto, R. Higuchi, Youn Chul Kim

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

Bioassay-guided fractionation of an H₂O extract of Artemisia feddei has furnished an inducible nitric oxide synthase (iNOS) inhibitory coumarin, scopoletin (1) and one of the inactive sesquiterpenes, achillin (2). Compound 1 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-γ (IFN- γ) plus lipopolysaccharide (LPS). The inhibition of NO synthesis of 1 was due to suppression of iNOS mRNA and iNOS protein, as determined by Northern and Western blotting, respectively.

Original language	English
Pages (from-to)	400-403
Number of pages	4
Journal	Planta medica
Volume	65
Issue number	5
DOIs	https://doi.org/10.1055/s-1999-14014
Publication status	Published - 1999

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1055/s-1999-14014

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abstract = "Bioassay-guided fractionation of an H2O extract of Artemisia feddei has furnished an inducible nitric oxide synthase (iNOS) inhibitory coumarin, scopoletin (1) and one of the inactive sesquiterpenes, achillin (2). Compound 1 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-γ (IFN- γ) plus lipopolysaccharide (LPS). The inhibition of NO synthesis of 1 was due to suppression of iNOS mRNA and iNOS protein, as determined by Northern and Western blotting, respectively.",

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T2 - An inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei

AU - Kang, Tai Hyun

AU - Pae, Hyun Ock

AU - Jeong, Sei Joon

AU - Yoo, Ji Chang

AU - Choi, Byung Min

AU - Jun, Chang Duk

AU - Chung, Hun Taeg

AU - Miyamoto, T.

AU - Higuchi, R.

AU - Kim, Youn Chul

PY - 1999

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AB - Bioassay-guided fractionation of an H2O extract of Artemisia feddei has furnished an inducible nitric oxide synthase (iNOS) inhibitory coumarin, scopoletin (1) and one of the inactive sesquiterpenes, achillin (2). Compound 1 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-γ (IFN- γ) plus lipopolysaccharide (LPS). The inhibition of NO synthesis of 1 was due to suppression of iNOS mRNA and iNOS protein, as determined by Northern and Western blotting, respectively.

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Scopoletin: An inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei

Abstract

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