Sappanin-type homoisoflavonoids from Sansevieria trifasciata Prain

Billy T. Tchegnitegni; Rémy B. Teponno; Chiaki Tanaka; Adeyemi F. Gabriel; Léon A. Tapondjou; Tomofumi Miyamoto

doi:10.1016/j.phytol.2015.04.017

Sappanin-type homoisoflavonoids from Sansevieria trifasciata Prain

Billy T. Tchegnitegni, Rémy B. Teponno, Chiaki Tanaka, Adeyemi F. Gabriel, Léon A. Tapondjou, Tomofumi Miyamoto

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Abstract Two new sappanin-type homoisoflavonoids, (3R)-7-hydroxy-8-methoxy-3′,4′-methylenedioxyhomoisoflavanone (trifasciatine A) 1 and (3R)-3,7-dihydroxy-8-methoxy-3′,4′-methylenedioxyhomoisoflavanone (trifasciatine B) 2 were isolated as minor components from the EtOAc soluble fraction of the methanol extract of Sansevieria trifasciata collected in Cameroon together with the known 1-(stearoyl)-glycerol 3 and spirosta-5,25(27)-dien-1β,3β-diol-1-O-α-l-rhamnopyranosyl-(1 → 2)-α-l-arabinopyranoside 4. Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR) and HRESIMS. Compounds 1 and 2 were screened for their antiproliferative activity on HeLa cells and no significant effect was observed when compare to 5-FU (fluorouracil) used as positive control.

Original language	English
Article number	936
Pages (from-to)	262-266
Number of pages	5
Journal	Phytochemistry Letters
Volume	12
DOIs	https://doi.org/10.1016/j.phytol.2015.04.017
Publication status	Published - Jun 16 2015

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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@article{69910cf2d37441f8815ac32a62c41984,

title = "Sappanin-type homoisoflavonoids from Sansevieria trifasciata Prain",

abstract = "Abstract Two new sappanin-type homoisoflavonoids, (3R)-7-hydroxy-8-methoxy-3′,4′-methylenedioxyhomoisoflavanone (trifasciatine A) 1 and (3R)-3,7-dihydroxy-8-methoxy-3′,4′-methylenedioxyhomoisoflavanone (trifasciatine B) 2 were isolated as minor components from the EtOAc soluble fraction of the methanol extract of Sansevieria trifasciata collected in Cameroon together with the known 1-(stearoyl)-glycerol 3 and spirosta-5,25(27)-dien-1β,3β-diol-1-O-α-l-rhamnopyranosyl-(1 → 2)-α-l-arabinopyranoside 4. Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR) and HRESIMS. Compounds 1 and 2 were screened for their antiproliferative activity on HeLa cells and no significant effect was observed when compare to 5-FU (fluorouracil) used as positive control.",

author = "Tchegnitegni, {Billy T.} and Teponno, {R{\'e}my B.} and Chiaki Tanaka and Gabriel, {Adeyemi F.} and Tapondjou, {L{\'e}on A.} and Tomofumi Miyamoto",

note = "Publisher Copyright: {\textcopyright} 2015 Phytochemical Society of Europe. Published by Elsevier B.V.",

year = "2015",

month = jun,

day = "16",

doi = "10.1016/j.phytol.2015.04.017",

language = "English",

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T1 - Sappanin-type homoisoflavonoids from Sansevieria trifasciata Prain

AU - Tchegnitegni, Billy T.

AU - Teponno, Rémy B.

AU - Tanaka, Chiaki

AU - Gabriel, Adeyemi F.

AU - Tapondjou, Léon A.

AU - Miyamoto, Tomofumi

PY - 2015/6/16

Y1 - 2015/6/16

N2 - Abstract Two new sappanin-type homoisoflavonoids, (3R)-7-hydroxy-8-methoxy-3′,4′-methylenedioxyhomoisoflavanone (trifasciatine A) 1 and (3R)-3,7-dihydroxy-8-methoxy-3′,4′-methylenedioxyhomoisoflavanone (trifasciatine B) 2 were isolated as minor components from the EtOAc soluble fraction of the methanol extract of Sansevieria trifasciata collected in Cameroon together with the known 1-(stearoyl)-glycerol 3 and spirosta-5,25(27)-dien-1β,3β-diol-1-O-α-l-rhamnopyranosyl-(1 → 2)-α-l-arabinopyranoside 4. Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR) and HRESIMS. Compounds 1 and 2 were screened for their antiproliferative activity on HeLa cells and no significant effect was observed when compare to 5-FU (fluorouracil) used as positive control.

AB - Abstract Two new sappanin-type homoisoflavonoids, (3R)-7-hydroxy-8-methoxy-3′,4′-methylenedioxyhomoisoflavanone (trifasciatine A) 1 and (3R)-3,7-dihydroxy-8-methoxy-3′,4′-methylenedioxyhomoisoflavanone (trifasciatine B) 2 were isolated as minor components from the EtOAc soluble fraction of the methanol extract of Sansevieria trifasciata collected in Cameroon together with the known 1-(stearoyl)-glycerol 3 and spirosta-5,25(27)-dien-1β,3β-diol-1-O-α-l-rhamnopyranosyl-(1 → 2)-α-l-arabinopyranoside 4. Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR) and HRESIMS. Compounds 1 and 2 were screened for their antiproliferative activity on HeLa cells and no significant effect was observed when compare to 5-FU (fluorouracil) used as positive control.

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JF - Phytochemistry Letters

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ER -

Sappanin-type homoisoflavonoids from Sansevieria trifasciata Prain

Abstract

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