Saponins from the roots of Nylandtia spinosa

Cheikh Diome, Anne Claire Mitaine-Offer, Tomofumi Miyamoto, Clément Delaude, Jean François Mirjolet, Olivier Duchamp, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


From the roots of Nylandtia spinosa, four new triterpene saponins, 3-O-β-D-glucopyranosylpresenegenin 28-O-β-D-galactopyranosyl- (1→4)-[α-L-arabinopyranosyl-(1→3)]-β-D-xylopyranosyl- (1→4)-[β-D-apiofuranosyl-(1→3)]-α-L-rhamnopyranosyl- (1→2)-β-D-fucopyranosyl ester (1), 3-O-β-D- glucopyranosylpresenegenin 28-O-β-D-galactopyranosyl-(1→4)-[α-L- arabinopyranosyl-(1→3)]-β-D-xylopyranosyl-(1→4) -α-L-rhamnopyranosyl-(1→2)-β-D-fucopyranosyl ester (2), 3-O-β-D-glucopyranosylpresenegenin 28-O-β-D-apiofuranosyl-(1→4)- [β-D-galactopyranosyl-(1→2)]-β-D-xylopyranosyl-(1→4) -α-L-rhamnopyranosyl-(1→2)-β-D-fucopyranosyl ester (3), and 3-O-β-D-glucopyranosylpresenegenin 28-O-β-D-apiofuranosyl-(1→3)- β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2) -β-D-fucopyranosyl ester (4), were isolated, together with the known tenuifolin. Their structures were established mainly by 2D NMR techniques and mass spectrometry. Compounds 1-4 were evaluated for cytotoxicity against HCT 116 and HT-29 human colon cancer cells, but were inactive (IC50 > 5 μg/mL).

Original languageEnglish
Pages (from-to)1680-1682
Number of pages3
JournalJournal of Natural Products
Issue number10
Publication statusPublished - Oct 2007

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Analytical Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry


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