Ruthenium-catalyzed asymmetric hydrogenation of N-Boc-indoles

Ryoichi Kuwano, Manabu Kashiwabara

Research output: Contribution to journalArticlepeer-review

171 Citations (Scopus)


Highly enantioselective hydrogenation of various N-Boc-indoles proceeded successfully in the presence of the ruthenium complex generated from an appropriate ruthenium precursor and a trans-chelate chiral bisphosphine PhTRAP. Various 2- or 3-substituted indoles were converted into chiral indolines with high enantiomeric excesses (up to 95% ee). The PhTRAP-ruthenium catalyst was able to promote the hydrogenation of 2,3-dimethylindoles, giving cis-2,3-dimethylindolines with 72% ee.

Original languageEnglish
Pages (from-to)2653-2655
Number of pages3
JournalOrganic letters
Issue number12
Publication statusPublished - Jun 8 2006

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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