Ru(CO)-salen-catalyzed synthesis of enantiopure aziridinyl ketones and formal asymmetric synthesis of (+)-PD 128907

Yasuaki Fukunaga; Tatsuya Uchida; Yutaro Ito; Kenji Matsumoto; Tsutomu Katsuki

doi:10.1021/ol302095r

Ru(CO)-salen-catalyzed synthesis of enantiopure aziridinyl ketones and formal asymmetric synthesis of (+)-PD 128907

Yasuaki Fukunaga, Tatsuya Uchida, Yutaro Ito, Kenji Matsumoto, Tsutomu Katsuki

Division for Experimental Natural Science

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Aziridination of vinyl ketones using SESN₃ in the presence Ru(CO)-salen complex 1 provides the enantiopure aziridinyl ketones that can serve as useful chiral building blocks. A formal asymmetric synthesis of (+)-PD 128907 was achieved in an eight-step sequence via aziridination.

Original language	English
Pages (from-to)	4658-4661
Number of pages	4
Journal	Organic letters
Volume	14
Issue number	17
DOIs	https://doi.org/10.1021/ol302095r
Publication status	Published - Sept 7 2012

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol302095r

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title = "Ru(CO)-salen-catalyzed synthesis of enantiopure aziridinyl ketones and formal asymmetric synthesis of (+)-PD 128907",

abstract = "Aziridination of vinyl ketones using SESN3 in the presence Ru(CO)-salen complex 1 provides the enantiopure aziridinyl ketones that can serve as useful chiral building blocks. A formal asymmetric synthesis of (+)-PD 128907 was achieved in an eight-step sequence via aziridination.",

author = "Yasuaki Fukunaga and Tatsuya Uchida and Yutaro Ito and Kenji Matsumoto and Tsutomu Katsuki",

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T1 - Ru(CO)-salen-catalyzed synthesis of enantiopure aziridinyl ketones and formal asymmetric synthesis of (+)-PD 128907

AU - Fukunaga, Yasuaki

AU - Uchida, Tatsuya

AU - Ito, Yutaro

AU - Matsumoto, Kenji

AU - Katsuki, Tsutomu

PY - 2012/9/7

Y1 - 2012/9/7

N2 - Aziridination of vinyl ketones using SESN3 in the presence Ru(CO)-salen complex 1 provides the enantiopure aziridinyl ketones that can serve as useful chiral building blocks. A formal asymmetric synthesis of (+)-PD 128907 was achieved in an eight-step sequence via aziridination.

AB - Aziridination of vinyl ketones using SESN3 in the presence Ru(CO)-salen complex 1 provides the enantiopure aziridinyl ketones that can serve as useful chiral building blocks. A formal asymmetric synthesis of (+)-PD 128907 was achieved in an eight-step sequence via aziridination.

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ER -

Ru(CO)-salen-catalyzed synthesis of enantiopure aziridinyl ketones and formal asymmetric synthesis of (+)-PD 128907

Abstract

All Science Journal Classification (ASJC) codes

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