TY - JOUR
T1 - ROS-mediated synthetic growth defect caused by impaired metabolism of sphingolipids and phosphatidylserine in budding yeast
AU - Toda, Takumi
AU - Urita, Atsuya
AU - Koga, Ayano
AU - Takayama, Chihiro
AU - Tani, Motohiro
N1 - Funding Information:
We wish to thank Drs. O. Kuge, T. Ogishima, and N. Miyata (Kyushu University) for discussions. This study was funded by a KAKENHI (18H02139) from the Ministry of Education, Culture, Sports, Science, and Technology, the Institute for Fermentation, Osaka, and the Noda Institute for Scientific Research, Japan.
Funding Information:
We wish to thank Drs. O. Kuge, T. Ogishima, and N. Miyata (Kyushu University) for discussions. This study was funded by a KAKENHI (18H02139) from the Ministry of Education, Culture, Sports, Science, and Technology, the Institute for Fermentation, Osaka, and the Noda Institute for Scientific Research, Japan.
Publisher Copyright:
© 2020 Japan Society for Bioscience, Biotechnology, and Agrochemistry.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Previously, we found that yeast exhibits a strong growth defect with the combination of a lack of gene involved in structural modification of sphingolipids and repression of the phosphatidylserine synthase gene. Here we found that the double gene mutation causes reactive oxygen species-mediated cell growth defect, which is suppressed by deletion of LEM3 encoding the subunit of phospholipid flippase.
AB - Previously, we found that yeast exhibits a strong growth defect with the combination of a lack of gene involved in structural modification of sphingolipids and repression of the phosphatidylserine synthase gene. Here we found that the double gene mutation causes reactive oxygen species-mediated cell growth defect, which is suppressed by deletion of LEM3 encoding the subunit of phospholipid flippase.
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U2 - 10.1080/09168451.2020.1810539
DO - 10.1080/09168451.2020.1810539
M3 - Article
C2 - 32842901
AN - SCOPUS:85089868593
SN - 0916-8451
VL - 84
SP - 2529
EP - 2532
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 12
ER -