Roles of prostaglandins and leukotrienes in acute inflammation caused by bacterial infection

Y. Yoshikai

Research output: Contribution to journalReview articlepeer-review

53 Citations (Scopus)

Abstract

Prostanoids, including prostaglandins and thromboxanes, are generated by the phospholipase A2/cyclooxygenase pathway, and leukotrienes are generated by the 5-lipoxygenase pathway from arachidonic acid. At physiological concentrations, vasodilator prostaglandins enhance the vascular permeability effects of histamine and bradykinin, and leukotrienes are important mediators of leukocyte accumulation during acute inflammation. On the other hand, prostaglandin metabolites such as cyclopentenone prostaglandins contribute to the resolution of acute inflammation through inhibition of nuclear factor-κB activation. Thus, arachidonic acid oxygenation products mediate diverse effects that induce and resolve acute inflammation caused by bacterial infection.

Original languageEnglish
Pages (from-to)257-263
Number of pages7
JournalCurrent Opinion in Infectious Diseases
Volume14
Issue number3
DOIs
Publication statusPublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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