TY - JOUR
T1 - Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells
AU - Sugiyama, Shigeru
AU - Nakabayashi, Kazuhiko
AU - Baba, Iwai
AU - Sasazuki, Takehiko
AU - Shirasawa, Senji
N1 - Funding Information:
This work was supported in part by a grant from the Ministry of Education, Science, Sports and Culture of Japan.
PY - 2005/11/11
Y1 - 2005/11/11
N2 - We have previously found that epiregulin, a member of epidermal growth factor superfamily, is involved in proinflammatory cytokine production in bone marrow-derived macrophages. In this report, to further assess the role of epiregulin in innate immunity, we measured IL-6 production levels upon lipopolysaccharide and peptidoglycan stimulation in antigen presenting cells including macrophages and dendritic cells. Our analyses using epiregulin-deficient mice with mixed and inbred genetic backgrounds revealed that epiregulin deficiency results in the reduction of IL-6 production levels in both cell types upon peptidoglycan stimulation, and that the extent of this reduction is more evident under the BALB/c background compared with the C57BL/6J background. These results indicated that epiregulin may have a critical role in the regulation of peptidoglycan-mediated proinflammatory cytokine production in antigen presenting cells and innate immunity.
AB - We have previously found that epiregulin, a member of epidermal growth factor superfamily, is involved in proinflammatory cytokine production in bone marrow-derived macrophages. In this report, to further assess the role of epiregulin in innate immunity, we measured IL-6 production levels upon lipopolysaccharide and peptidoglycan stimulation in antigen presenting cells including macrophages and dendritic cells. Our analyses using epiregulin-deficient mice with mixed and inbred genetic backgrounds revealed that epiregulin deficiency results in the reduction of IL-6 production levels in both cell types upon peptidoglycan stimulation, and that the extent of this reduction is more evident under the BALB/c background compared with the C57BL/6J background. These results indicated that epiregulin may have a critical role in the regulation of peptidoglycan-mediated proinflammatory cytokine production in antigen presenting cells and innate immunity.
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U2 - 10.1016/j.bbrc.2005.09.050
DO - 10.1016/j.bbrc.2005.09.050
M3 - Article
C2 - 16182244
AN - SCOPUS:25844508912
SN - 0006-291X
VL - 337
SP - 271
EP - 274
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -