TY - JOUR
T1 - Role of AhR/ARNT system in skin homeostasis
AU - Furue, Masutaka
AU - Takahara, Masakazu
AU - Nakahara, Takeshi
AU - Uchi, Hiroshi
N1 - Funding Information:
Acknowledgments This work was partly supported by grants from The Ministry of Health, Labour and Welfare; The Ministry of Education, Culture, Sports, Science and Technology; and the Environment Technology Development Fund of the Ministry of the Environment, Japan.
Publisher Copyright:
© 2014, The Author(s).
PY - 2014/11
Y1 - 2014/11
N2 - Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that binds to structurally diverse synthetic and naturally occurring chemicals including dioxins, flavonoids, tryptophan photoproducts, and Malassezia metabolites. Upon binding to its ligands, cytoplasmic AhR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT), and mediates numerous biological and toxicological effects by inducing the transcription of various AhR-responsive genes. AhR ligation controls oxidation/antioxidation, epidermal barrier function, photo-induced response, melanogenesis, and innate immunity. This review summarizes recent advances in the understanding of the regulatory mechanisms of skin homeostasis mediated by the AhR/ARNT system.
AB - Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that binds to structurally diverse synthetic and naturally occurring chemicals including dioxins, flavonoids, tryptophan photoproducts, and Malassezia metabolites. Upon binding to its ligands, cytoplasmic AhR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT), and mediates numerous biological and toxicological effects by inducing the transcription of various AhR-responsive genes. AhR ligation controls oxidation/antioxidation, epidermal barrier function, photo-induced response, melanogenesis, and innate immunity. This review summarizes recent advances in the understanding of the regulatory mechanisms of skin homeostasis mediated by the AhR/ARNT system.
UR - http://www.scopus.com/inward/record.url?scp=84931839940&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931839940&partnerID=8YFLogxK
U2 - 10.1007/s00403-014-1481-7
DO - 10.1007/s00403-014-1481-7
M3 - Review article
C2 - 24966027
AN - SCOPUS:84931839940
SN - 0340-3696
VL - 306
SP - 769
EP - 779
JO - Archives of Dermatological Research
JF - Archives of Dermatological Research
IS - 9
ER -