Role of 5-hydroxytryptamine 2C receptors in marble-burying behavior in mice

Nobuaki Egashira; Ryoko Okuno; Atsunori Shirakawa; Masaki Nagao; Kenichi Mishima; Katsunori Iwasaki; Ryozo Oishi; Michihiro Fujiwara

doi:10.1248/bpb.35.376

Role of 5-hydroxytryptamine _2C receptors in marble-burying behavior in mice

Nobuaki Egashira, Ryoko Okuno, Atsunori Shirakawa, Masaki Nagao, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

Pharmacy

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Abstract

We examined the role of 5-hydroxytryptamine _2C (5-HT _2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT _2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT _2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT _2C receptors play a role in marble-burying behavior in mice.

Original language	English
Pages (from-to)	376-379
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	35
Issue number	3
DOIs	https://doi.org/10.1248/bpb.35.376
Publication status	Published - Mar 2012

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science

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title = "Role of 5-hydroxytryptamine 2C receptors in marble-burying behavior in mice",

abstract = "We examined the role of 5-hydroxytryptamine 2C (5-HT 2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT 2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT 2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT 2C receptors play a role in marble-burying behavior in mice.",

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AU - Egashira, Nobuaki

AU - Okuno, Ryoko

AU - Shirakawa, Atsunori

AU - Nagao, Masaki

AU - Mishima, Kenichi

AU - Iwasaki, Katsunori

AU - Oishi, Ryozo

AU - Fujiwara, Michihiro

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Role of 5-hydroxytryptamine _2C receptors in marble-burying behavior in mice

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