RNA Tectonics (tectoRNA) for RNA nanostructure design and its application in synthetic biology

Junya Ishikawa, Hiroyuki Furuta, Yoshiya Ikawa

    Research output: Contribution to journalReview articlepeer-review

    43 Citations (Scopus)


    RNA molecules are versatile biomaterials that act not only as DNA-like genetic materials but also have diverse functions in regulation of cellular biosystems. RNA is capable of regulating gene expression by sequence-specific hybridization. This feature allows the design of RNA-based artificial gene regulators (riboregulators). RNA can also build complex two-dimensional (2D) and 3D nanostructures, which afford protein-like functions and make RNA an attractive material for nanobiotechnology. RNA tectonics is a methodology in RNA nanobiotechnology for the design and construction of RNA nanostructures/nanoobjects through controlled self-assembly of modular RNA units (tectoRNAs). RNA nanostructures designed according to the concept of RNA tectonics are also attractive as tools in synthetic biology, but in vivo RNA tectonics is still in the early stages. This review presents a summary of the achievements of RNA tectonics and its related researches in vitro, and also introduces recent developments that facilitated the use of RNA nanostructures in bacterial cells.

    Original languageEnglish
    Pages (from-to)651-664
    Number of pages14
    JournalWiley Interdisciplinary Reviews: RNA
    Issue number6
    Publication statusPublished - Nov 2013

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Molecular Biology


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