Right entorhinal cortical thickness is associated with Mini-Mental State Examination scores from multi-country datasets using MRI

Koji Yamashita, Takahiro Kuwashiro, Kensuke Ishikawa, Kiyomi Furuya, Shino Harada, Seitaro Shin, Noriaki Wada, Chika Hirakawa, Yasushi Okada, Tomoyuki Noguchi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Purpose: To discover common biomarkers correlating with the Mini-Mental State Examination (MMSE) scores from multi-country MRI datasets. Methods: The first dataset comprised 112 subjects (49 men, 63 women; range, 46–94 years) at the National Hospital Organization Kyushu Medical Center. A second dataset comprised 300 subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (177 men, 123 women; range, 57–91 years). Three-dimensional T1-weighted MR images were collected from both datasets. In total, 14 deep gray matter volumes and 70 cortical thicknesses were obtained from MR images using FreeSurfer software. Total hippocampal volume and the ratio of hippocampus to cerebral volume were also calculated. Correlations between each variable and MMSE scores were assessed using Pearson’s correlation coefficient. Parameters with moderate correlation coefficients (r > 0.3) from each dataset were determined as independent variables and evaluated using general linear model (GLM) analyses. Results: In Pearson’s correlation coefficient, total and bilateral hippocampal volumes, right amygdala volume, and right entorhinal cortex (ERC) thickness showed moderate correlation coefficients (r > 0.3) with MMSE scores from the first dataset. The ADNI dataset showed moderate correlations with MMSE scores in more variables, including bilateral ERC thickness and hippocampal volume. GLM analysis revealed that right ERC thickness correlated significantly with MMSE score in both datasets. Cortical thicknesses of the left parahippocampal gyrus, left inferior parietal lobe, and right fusiform gyrus also significantly correlated with MMSE score in the ADNI dataset (p < 0.05). Conclusion: A positive correlation between right ERC thickness and MMSE score was identified from multi-country datasets.

Original languageEnglish
Pages (from-to)279-288
Number of pages10
Issue number2
Publication statusPublished - Feb 2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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