Rhodium-catalyzed synthesis of benzofurans by the reaction of ketones and O-difluorobenzenes

Mieko Arisawa; Soichiro Nakane; Manabu Kuwajima; Masahiko Yamaguchi

doi:10.3987/COM-12-S(N)57

Rhodium-catalyzed synthesis of benzofurans by the reaction of ketones and O-difluorobenzenes

Mieko Arisawa, Soichiro Nakane, Manabu Kuwajima, Masahiko Yamaguchi

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

In the presence of catalytic amounts of RhH(PPh3)4 and 1,2- bis(diphenylphosphino)ethane (dppe), ketones reacted with o-difluorobenzenes giving benzofurans in high yields. The ?-arylation of ketones and furan cyclization proceeded without using a base. Benzofuran cyclization was applied to substituted pentafluorobenzenes to give 6-substituted-4,5,7- trifluorobenzofuranes.

Original language	English
Pages (from-to)	1103-1118
Number of pages	16
Journal	Heterocycles
Volume	86
Issue number	2
DOIs	https://doi.org/10.3987/COM-12-S(N)57
Publication status	Published - 2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "In the presence of catalytic amounts of RhH(PPh3)4 and 1,2- bis(diphenylphosphino)ethane (dppe), ketones reacted with o-difluorobenzenes giving benzofurans in high yields. The ?-arylation of ketones and furan cyclization proceeded without using a base. Benzofuran cyclization was applied to substituted pentafluorobenzenes to give 6-substituted-4,5,7- trifluorobenzofuranes.",

author = "Mieko Arisawa and Soichiro Nakane and Manabu Kuwajima and Masahiko Yamaguchi",

year = "2012",

doi = "10.3987/COM-12-S(N)57",

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journal = "Heterocycles",

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T1 - Rhodium-catalyzed synthesis of benzofurans by the reaction of ketones and O-difluorobenzenes

AU - Arisawa, Mieko

AU - Nakane, Soichiro

AU - Kuwajima, Manabu

AU - Yamaguchi, Masahiko

PY - 2012

Y1 - 2012

N2 - In the presence of catalytic amounts of RhH(PPh3)4 and 1,2- bis(diphenylphosphino)ethane (dppe), ketones reacted with o-difluorobenzenes giving benzofurans in high yields. The ?-arylation of ketones and furan cyclization proceeded without using a base. Benzofuran cyclization was applied to substituted pentafluorobenzenes to give 6-substituted-4,5,7- trifluorobenzofuranes.

AB - In the presence of catalytic amounts of RhH(PPh3)4 and 1,2- bis(diphenylphosphino)ethane (dppe), ketones reacted with o-difluorobenzenes giving benzofurans in high yields. The ?-arylation of ketones and furan cyclization proceeded without using a base. Benzofuran cyclization was applied to substituted pentafluorobenzenes to give 6-substituted-4,5,7- trifluorobenzofuranes.

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VL - 86

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JO - Heterocycles

JF - Heterocycles

IS - 2

ER -

Rhodium-catalyzed synthesis of benzofurans by the reaction of ketones and O-difluorobenzenes

Abstract

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