Rhodium-catalyzed organothio exchange reaction of α-organothioketones with disulfides

Mieko Arisawa, Fumihiko Toriyama, Masahiko Yamaguchi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


RhH(PPh3)4 and 1,2-bis(diphenylphosphino)ethane (dppe) catalyzed the organothio exchange reaction of α-organothioketones and organic disulfides. The reaction was affected by the structure of the substrate: α-phenylthio and α-alkylthio aryl ketones reacted effectively with diaryl and dialkyl disulfides; α-phenylthio dialkyl ketones reacted with diaryl disulfides but not with dialkyl disulfides; diaryl disulfides with electron-donating p-substituents were more reactive than those with electron-withdrawing p-substituents.

Original languageEnglish
Pages (from-to)1349-1352
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Issue number10
Publication statusPublished - Oct 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery


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