Rhodium-catalyzed intramolecular silylation of unactivated C(sp 3)-H bonds

Yoichiro Kuninobu, Takahiro Nakahara, Hirotaka Takeshima, Kazuhiko Takai

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)


The treatment of a variety of hydrosilanes, each incorporating a benzylic C(sp3)-H bond, with a rhodium catalyst resulted in intramolecular dehydrogenative silylation. This silylation reaction was found to occur at typically unreactive C(sp3)-H bonds located at terminal positions on alkyl chains. Interestingly, the rhodium catalyst also promoted regioselective silylation at a site internal to an alkyl chain.

Original languageEnglish
Pages (from-to)426-428
Number of pages3
JournalOrganic letters
Issue number2
Publication statusPublished - Jan 18 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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