A rhodium complex derived from RhH(PPh3)4 and Me 2PhP catalyzed the carbothiolation reaction of 1-alkylthio-1-alkynes and 1,4-diaryl-1,3-butadiynes giving (Z)-4-alkylthio-4-aryl-3-arylethynyl-3- buten-1-ynes. Terminal alkynes such as 1-decyne and (t-butylthio)acetylene underwent the carbothiolation reaction using a RhH(PPh3) 4-dppb catalyst. The reactions proceeded via cis-addition with C-C bond formation at the less hindered acetylene carbon.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry