Rheological aspects of conformational change and molecular aggregation of macromolecules

Research output: Chapter in Book/Report/Conference proceedingChapter


When the temperature of a dilute polymer solution is changed gradually far below the Θ point, the conformation of individual polymer chains changes from a random coil to a compact globular state (coil-globule transition), followed by intermolecular aggregation owing to phase separation. In this chapter, the coil-globule transition and the aggregation behavior in dilute solutions of typical neutral synthetic homopolymers, poly(N-isopropylacrylamide) (PNIPAM) and poly(methyl methacrylate) (PMMA), are reviewed, and some rheological aspects of the kinetics of chain collapse and chain aggregation are demonstrated. The applicability of the rheological concepts derived from the aggregation behavior of synthetic homopolymers to that of intrinsically disordered proteins (IDPs) is considered.

Original languageEnglish
Title of host publicationNano/Micro Science and Technology in Biorheology
Subtitle of host publicationPrinciples, Methods, and Applications
PublisherSpringer Japan
Number of pages35
ISBN (Electronic)9784431548867
ISBN (Print)9784431548850
Publication statusPublished - Jan 1 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)


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