Rheological aspects of conformational change and molecular aggregation of macromolecules

Yasuyuki Maki

doi:10.1007/978-4-431-54886-7_2

Rheological aspects of conformational change and molecular aggregation of macromolecules

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

When the temperature of a dilute polymer solution is changed gradually far below the Θ point, the conformation of individual polymer chains changes from a random coil to a compact globular state (coil-globule transition), followed by intermolecular aggregation owing to phase separation. In this chapter, the coil-globule transition and the aggregation behavior in dilute solutions of typical neutral synthetic homopolymers, poly(N-isopropylacrylamide) (PNIPAM) and poly(methyl methacrylate) (PMMA), are reviewed, and some rheological aspects of the kinetics of chain collapse and chain aggregation are demonstrated. The applicability of the rheological concepts derived from the aggregation behavior of synthetic homopolymers to that of intrinsically disordered proteins (IDPs) is considered.

Original language	English
Title of host publication	Nano/Micro Science and Technology in Biorheology
Subtitle of host publication	Principles, Methods, and Applications
Publisher	Springer Japan
Pages	7-41
Number of pages	35
ISBN (Electronic)	9784431548867
ISBN (Print)	9784431548850
DOIs	https://doi.org/10.1007/978-4-431-54886-7_2
Publication status	Published - Jan 1 2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)
Engineering(all)

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10.1007/978-4-431-54886-7_2

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Rheological aspects of conformational change and molecular aggregation of macromolecules

Abstract

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