RhCl3-catalyzed disulfide exchange reaction of insulin and dithiodiglycolic acid

Mieko Arisawa; Manabu Kuwajima; Atsushi Suwa; Masahiko Yamaguchi

doi:10.3987/COM-09-S(S)110

RhCl₃-catalyzed disulfide exchange reaction of insulin and dithiodiglycolic acid

Mieko Arisawa
, Manabu Kuwajima
, Atsushi Suwa
, Masahiko Yamaguchi

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

RhCl₃ catalyzed the alkylthio exchange reaction of insulin and dithiodiglycolic acid in water under homogeneous conditions. Insulin was rapidly consumed, and mono- and bis-exchanged insulin were formed along with the disulfide exchanged A and B chain. The disulfide bond at the A7/B7 was initially exchanged, which was followed by the A6/A11 and A20/B19 disulfides.

Original language	English
Pages (from-to)	1239-1248
Number of pages	10
Journal	Heterocycles
Volume	80
Issue number	2
DOIs	https://doi.org/10.3987/COM-09-S(S)110
Publication status	Published - Mar 1 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmacology
Organic Chemistry

Access to Document

10.3987/COM-09-S(S)110

Cite this

@article{b5effd74cc644dcbbfeb81614b55e811,

title = "RhCl3-catalyzed disulfide exchange reaction of insulin and dithiodiglycolic acid",

abstract = "RhCl3 catalyzed the alkylthio exchange reaction of insulin and dithiodiglycolic acid in water under homogeneous conditions. Insulin was rapidly consumed, and mono- and bis-exchanged insulin were formed along with the disulfide exchanged A and B chain. The disulfide bond at the A7/B7 was initially exchanged, which was followed by the A6/A11 and A20/B19 disulfides.",

keywords = "A7/B7 Disulfide, Catalysis, Disulfide Exchange Reaction, Insulin, Rhodium Chloride",

author = "Mieko Arisawa and Manabu Kuwajima and Atsushi Suwa and Masahiko Yamaguchi",

year = "2010",

month = mar,

day = "1",

doi = "10.3987/COM-09-S(S)110",

language = "English",

volume = "80",

pages = "1239--1248",

journal = "Heterocycles",

issn = "0385-5414",

publisher = "Japan Institute of Heterocyclic Chemistry",

number = "2",

}

TY - JOUR

T1 - RhCl3-catalyzed disulfide exchange reaction of insulin and dithiodiglycolic acid

AU - Arisawa, Mieko

AU - Kuwajima, Manabu

AU - Suwa, Atsushi

AU - Yamaguchi, Masahiko

PY - 2010/3/1

Y1 - 2010/3/1

N2 - RhCl3 catalyzed the alkylthio exchange reaction of insulin and dithiodiglycolic acid in water under homogeneous conditions. Insulin was rapidly consumed, and mono- and bis-exchanged insulin were formed along with the disulfide exchanged A and B chain. The disulfide bond at the A7/B7 was initially exchanged, which was followed by the A6/A11 and A20/B19 disulfides.

AB - RhCl3 catalyzed the alkylthio exchange reaction of insulin and dithiodiglycolic acid in water under homogeneous conditions. Insulin was rapidly consumed, and mono- and bis-exchanged insulin were formed along with the disulfide exchanged A and B chain. The disulfide bond at the A7/B7 was initially exchanged, which was followed by the A6/A11 and A20/B19 disulfides.

KW - A7/B7 Disulfide

KW - Catalysis

KW - Disulfide Exchange Reaction

KW - Insulin

KW - Rhodium Chloride

UR - https://www.scopus.com/pages/publications/77955691323

UR - https://www.scopus.com/pages/publications/77955691323#tab=citedBy

U2 - 10.3987/COM-09-S(S)110

DO - 10.3987/COM-09-S(S)110

M3 - Article

AN - SCOPUS:77955691323

SN - 0385-5414

VL - 80

SP - 1239

EP - 1248

JO - Heterocycles

JF - Heterocycles

IS - 2

ER -

RhCl₃-catalyzed disulfide exchange reaction of insulin and dithiodiglycolic acid

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this