RhCl3-catalyzed disulfide exchange reaction of insulin and dithiodiglycolic acid

Mieko Arisawa; Manabu Kuwajima; Atsushi Suwa; Masahiko Yamaguchi

doi:10.3987/COM-09-S(S)110

RhCl₃-catalyzed disulfide exchange reaction of insulin and dithiodiglycolic acid

Mieko Arisawa, Manabu Kuwajima, Atsushi Suwa, Masahiko Yamaguchi

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

RhCl₃ catalyzed the alkylthio exchange reaction of insulin and dithiodiglycolic acid in water under homogeneous conditions. Insulin was rapidly consumed, and mono- and bis-exchanged insulin were formed along with the disulfide exchanged A and B chain. The disulfide bond at the A7/B7 was initially exchanged, which was followed by the A6/A11 and A20/B19 disulfides.

Original language	English
Pages (from-to)	1239-1248
Number of pages	10
Journal	Heterocycles
Volume	80
Issue number	2
DOIs	https://doi.org/10.3987/COM-09-S(S)110
Publication status	Published - Mar 1 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "RhCl3 catalyzed the alkylthio exchange reaction of insulin and dithiodiglycolic acid in water under homogeneous conditions. Insulin was rapidly consumed, and mono- and bis-exchanged insulin were formed along with the disulfide exchanged A and B chain. The disulfide bond at the A7/B7 was initially exchanged, which was followed by the A6/A11 and A20/B19 disulfides.",

author = "Mieko Arisawa and Manabu Kuwajima and Atsushi Suwa and Masahiko Yamaguchi",

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T1 - RhCl3-catalyzed disulfide exchange reaction of insulin and dithiodiglycolic acid

AU - Arisawa, Mieko

AU - Kuwajima, Manabu

AU - Suwa, Atsushi

AU - Yamaguchi, Masahiko

PY - 2010/3/1

Y1 - 2010/3/1

N2 - RhCl3 catalyzed the alkylthio exchange reaction of insulin and dithiodiglycolic acid in water under homogeneous conditions. Insulin was rapidly consumed, and mono- and bis-exchanged insulin were formed along with the disulfide exchanged A and B chain. The disulfide bond at the A7/B7 was initially exchanged, which was followed by the A6/A11 and A20/B19 disulfides.

AB - RhCl3 catalyzed the alkylthio exchange reaction of insulin and dithiodiglycolic acid in water under homogeneous conditions. Insulin was rapidly consumed, and mono- and bis-exchanged insulin were formed along with the disulfide exchanged A and B chain. The disulfide bond at the A7/B7 was initially exchanged, which was followed by the A6/A11 and A20/B19 disulfides.

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U2 - 10.3987/COM-09-S(S)110

DO - 10.3987/COM-09-S(S)110

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JO - Heterocycles

JF - Heterocycles

IS - 2

ER -

RhCl₃-catalyzed disulfide exchange reaction of insulin and dithiodiglycolic acid

Abstract

All Science Journal Classification (ASJC) codes

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