Response to osteoblastic cells of bioactive organic-inorganic hybrid

Y. Aburatani, T. Uchida, Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)


Organically modified silicate gels were synthesized starting from ploy(dimethylsiloxane), tetraethoxysilane, calcium nitrate, and colloidal silica through sol-gel processing. In vitro apatite deposition on the colloidal silica containing hybrids in a simulated body fluid of the Kokubo recipe was confirmed, indicating they were bioactive. Cell proliferation for the hybrid gels with the colloidal silica was better than the colloidal silica free gels. The cells cultured for 7 days on the hybrid gels with colloidal silica expanded their pseudopodium and were well attached. In contrast, the cells were hardly observable on the colloidal silica free gels. Thus, the hybrids with colloidal silica are cytocompatible as well as bioactive.

Original languageEnglish
Pages (from-to)683-686
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2003
Externally publishedYes
EventProceedings of the 15th International Symposium on Ceramics in Medicine; The Annual Meeting of the International Society for Ceramics in Medicine - Sydney, NSW, Australia
Duration: Dec 4 2002Dec 8 2002

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering


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