Resetting the Epigenome beyond Pluripotency in the Germline

Katsuhiko Hayashi, M. Azim Surani

Research output: Contribution to journalReview articlepeer-review

75 Citations (Scopus)


Germ cells undergo comprehensive epigenetic reprogramming toward acquiring fitness for pluripotency and totipotency. Notably, the full extent of the epigenetic reprogramming experienced by germ cells remains unmatched by attempts to experimentally restore pluripotency in somatic cells. We propose that the defects present in experimentally generated cells are corrected upon differentiation into the germ cell lineage, as has been observed in cases of germline transmission. Unraveling the mechanisms responsible for germ cell-specific epigenetic reprogramming will likely have important implications for both basic and clinical stem cell research.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalCell stem cell
Issue number6
Publication statusPublished - Jun 5 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Cell Biology


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