Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice

Ryo Ozuru; Shohei Wakao; Takahiro Tsuji; Naoya Ohara; Takashi Matsuba; Muhammad Y. Amuran; Junko Isobe; Morio Iino; Naoki Nishida; Sari Matsumoto; Kimiharu Iwadate; Noriko Konishi; Kaori Yasuda; Kosuke Tashiro; Misato Hida; Arisato Yadoiwa; Shinsuke Kato; Eijiro Yamashita; Sohkichi Matsumoto; Yoichi Kurozawa; Mari Dezawa; Jun Fujii

doi:10.1016/j.ymthe.2019.09.023

Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice

Ryo Ozuru, Shohei Wakao, Takahiro Tsuji, Naoya Ohara, Takashi Matsuba, Muhammad Y. Amuran, Junko Isobe, Morio Iino, Naoki Nishida, Sari Matsumoto, Kimiharu Iwadate, Noriko Konishi, Kaori Yasuda, Kosuke Tashiro, Misato Hida, Arisato Yadoiwa, Shinsuke Kato, Eijiro Yamashita, Sohkichi Matsumoto, Yoichi KurozawaMari Dezawa, Jun Fujii

Systems Biology

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

NOD-SCID mice orally inoculated with 9 × 10⁹ colony-forming units of Shiga toxin-producing Escherichia coli (STEC) O111 and treated 48 h later with an intravenous injection of 5 × 10⁴ human bone marrow-derived multilineage-differentiating stress-enduring (Muse) cells exhibited 100% survival. Thus, the intravenous administration of Muse cells might be a candidate therapeutic approach for preventing acute encephalopathy after STEC infection.

Original language	English
Pages (from-to)	100-118
Number of pages	19
Journal	Molecular Therapy
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.ymthe.2019.09.023
Publication status	Published - Jan 8 2020

All Science Journal Classification (ASJC) codes

Molecular Medicine
Molecular Biology
Genetics
Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ymthe.2019.09.023

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Ozuru, R., Wakao, S., Tsuji, T., Ohara, N., Matsuba, T., Amuran, M. Y., Isobe, J., Iino, M., Nishida, N., Matsumoto, S., Iwadate, K., Konishi, N., Yasuda, K., Tashiro, K., Hida, M., Yadoiwa, A., Kato, S., Yamashita, E., Matsumoto, S., ... Fujii, J. (2020). Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice. Molecular Therapy, 28(1), 100-118. https://doi.org/10.1016/j.ymthe.2019.09.023

Ozuru, R, Wakao, S, Tsuji, T, Ohara, N, Matsuba, T, Amuran, MY, Isobe, J, Iino, M, Nishida, N, Matsumoto, S, Iwadate, K, Konishi, N, Yasuda, K, Tashiro, K, Hida, M, Yadoiwa, A, Kato, S, Yamashita, E, Matsumoto, S, Kurozawa, Y, Dezawa, M & Fujii, J 2020, 'Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice', Molecular Therapy, vol. 28, no. 1, pp. 100-118. https://doi.org/10.1016/j.ymthe.2019.09.023

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abstract = "NOD-SCID mice orally inoculated with 9 × 109 colony-forming units of Shiga toxin-producing Escherichia coli (STEC) O111 and treated 48 h later with an intravenous injection of 5 × 104 human bone marrow-derived multilineage-differentiating stress-enduring (Muse) cells exhibited 100% survival. Thus, the intravenous administration of Muse cells might be a candidate therapeutic approach for preventing acute encephalopathy after STEC infection.",

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AU - Ozuru, Ryo

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AU - Tsuji, Takahiro

AU - Ohara, Naoya

AU - Matsuba, Takashi

AU - Amuran, Muhammad Y.

AU - Isobe, Junko

AU - Iino, Morio

AU - Nishida, Naoki

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AU - Kato, Shinsuke

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AU - Kurozawa, Yoichi

AU - Dezawa, Mari

AU - Fujii, Jun

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Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice

Abstract

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