TY - JOUR
T1 - Report of the committee for establishment of the response evaluation criteria of antifungal therapy for oral candidiasis
AU - Nakagawa, Yoichi
AU - Oneyama, Takahiro
AU - Terai, Haruhiko
AU - Kanekawa, Akihiro
AU - Iwabuchi, Hiroshi
AU - Miyake, Satoshi
AU - Hasegawa, Isao
AU - Nishikawa, Masanori
AU - Nakayama, Hideki
AU - Nishimura, Satoshi
AU - Hayashida, Jun Nosuke
AU - Saito, Kenichi
AU - Onizawa, Kojiro
AU - Fukuda, Masayuki
AU - Niimi, Kanae
AU - Shibahara, Takahiko
AU - Jinbu, Yoshinori
AU - Kawamata, Hitoshi
AU - Tsurumoto, Akihisa
AU - Satoh, Tazuko
AU - Ishibashi, Katsunori
AU - Kaneko, Akihiro
AU - Miyasaka, Takahiro
AU - Kamikawa, Yoshiaki
AU - Kuriyama, Tomoari
AU - Maeda, Nobuko
AU - Yamada, Shoji
AU - Sato, Tsutomu
AU - Ikeda, Fumiaki
AU - Kobayashi, Intetsu
PY - 2011/4
Y1 - 2011/4
N2 - Purpose: The purpose of the study was to establish the response evaluation criteria of antifungal agents for oral candidiasis. Methods: A multicenter open-label trial was conducted. The patients with oral candidiasis were treated by an antifungal agent, itraconazole, and the response to the agent was evaluated according to the protocoL A multiple regression analysis was employed to examine the relative contribution of clinical signs and symptoms, including redness, white papules, atrophy of the papilla of the tongue, pain and soreness to the global evaluation of the responses judged by the attending physician. The global evaluation of the responses was rated as markedly improved, moderately improved or unchanged. Results: The multiple regression analysis showed that redness of the tongue and palate, white papules on the tongue, atrophy of the papillae of the tongue, and pain were associated with the global evaluation of the responses judged by the attending physician. Conclusion: Evaluation of these signs and symptoms could provide useful response information about antifungal therapy for oral candidiasis patients. Further studies will therefore be needed to verify the results of the present study.
AB - Purpose: The purpose of the study was to establish the response evaluation criteria of antifungal agents for oral candidiasis. Methods: A multicenter open-label trial was conducted. The patients with oral candidiasis were treated by an antifungal agent, itraconazole, and the response to the agent was evaluated according to the protocoL A multiple regression analysis was employed to examine the relative contribution of clinical signs and symptoms, including redness, white papules, atrophy of the papilla of the tongue, pain and soreness to the global evaluation of the responses judged by the attending physician. The global evaluation of the responses was rated as markedly improved, moderately improved or unchanged. Results: The multiple regression analysis showed that redness of the tongue and palate, white papules on the tongue, atrophy of the papillae of the tongue, and pain were associated with the global evaluation of the responses judged by the attending physician. Conclusion: Evaluation of these signs and symptoms could provide useful response information about antifungal therapy for oral candidiasis patients. Further studies will therefore be needed to verify the results of the present study.
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M3 - Article
AN - SCOPUS:79956342906
SN - 0288-1012
VL - 30
SP - 30
EP - 40
JO - ORAL THERAPEUTICS AND PHARMACOLOGY
JF - ORAL THERAPEUTICS AND PHARMACOLOGY
IS - 1
ER -